Paolo M Soprano

Ph.D. student in Translational Medicine and II level University Master in Regulatory Affairs. His research is focused on the impact of TPO mimetic on megakaryocyte function either in physiological and pathological conditions (Inherited Thrombocytopenia). He is interested in drug testing on human megakaryocytes using silk-based 3D bone marrow models. Specifically, he is exploiting the benefits of silk fibroin biomaterial to develop 3D models mimicking the architecture of the human bone marrow niche and understand the mechanisms affecting impaired megakaryopoiesis and platelet production. Also, he has expertise in the 3D culture and differentiation of human induced pluripotent stem cells to produce platelets for transfusion purposes.