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个人简介
Immune responses are initiated when T cells recognize antigens displayed by antigen presenting cells (APC). Classically, T cell recognition is towards peptide antigens displayed on APC by MHC molecules. More recently, lipid antigens were found to be similarly displayed by the MHC-like molecule, CD1, and recognized by an unconventional class of T cells, including NKT cells. We are interested in exploring the biology of lipid antigen recognition by T cells, and the role this has in a number of human diseases, including autoimmune diseases such as multiple sclerosis, diabetes and lupus, infectious diseases as well as inflammatory diseases such as atherosclerosis.
We have recently discovered a new role for the serum lipoprotein apoE in the immune response to lipid antigens. We will continue to explore the role of apolipoproteins in lipid antigen presentation as this has particular relevance to diseases such as atherosclerosis and autoimmune disease.
A major endeavor will be to identify lipid and glycolipid antigens that are presented by CD1 to T cells in various physiological settings and the role they play in disease. This will involve screening of candidate lipid antigens, as well as discovery approaches to find novel lipid antigens from various biological sources (cells, tissues or blood).
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论文共 44 篇作者统计合作学者相似作者
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Jessica Tuengel,Sanya Ranchal,Alexandra Maslova, Gurpreet Aulakh,Maria Papadopoulou,Sibyl Drissler,Bing Cai, Cetare Mohsenzadeh-Green,Hugo Soudeyns,Sara Mostafavi,Peter van den Elzen,David Vermijlen,Laura Cook,Soren Gantt
Virusesno. 10 (2021): 1987-1987
Bloodno. 15 (2013): 2600-8
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Ya-Jen Chang,Hye Young Kim,Lee A Albacker,Hyun Hee Lee,Nicole Baumgarth,Shizuo Akira,Paul B Savage,Shin Endo,Takashi Yamamura,Janneke Maaskant,Naoki Kitano, Abel Singh,Apoorva Bhatt,Gurdyal S Besra,Peter van den Elzen,Ben Appelmelk,Richard W Franck,Guangwu Chen,Rosemarie H DeKruyff,Michio Shimamura,Petr Illarionov,Dale T Umetsu
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#Papers: 45
#Citation: 1438
H-Index: 17
G-Index: 26
Sociability: 6
Diversity: 3
Activity: 1
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