Oleksandr Kobzar - Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine

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The current researche interests are focused on searching for inhibitors of therapeutically important enzymes such as protein tyrosine phosphatases, cholinesterases, xanthine oxidase, dihydrofolate reductase, glutathione S-transferase, and leucine aminopeptidase. The methods consists in using enzyme inhibition kinetics, molecular docking, and molecular dynamics.

Research Interests

Papers共 49 篇Author StatisticsCo-AuthorSimilar Experts

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Design, Synthesis, and Xanthine Oxidase Inhibitory Activity of 4-(5-aminosubstituted-4-cyanooxazol-2-yl)benzoic Acids

Oleksandr Kobzar, Alona Beiko,Danylo Merzhyievskyi,Oleg Shablykin,Volodymyr Brovarets,Vsevolod Tanchuk,Andriy Vovk

ChemMedChemno. 21 (2024): e202400478-e202400478

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ОСОБЛИВОСТІ РЕАЛІЗАЦІЇ ПРАВООХОРОННОЇ ФУНКЦІЇ ДЕРЖАВИ В УМОВАХ ДІЇ ПРАВОВОГО РЕЖИМУ ВОЄННОГО СТАНУ В УКРАЇНІ

Олександр Кобзар, Максим Романов

Науковий вісник Київського інституту Національної гвардії Україниpp.79-86, (2024)

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Trapping of Thermally Generated Ortho- and Para-Quinone Methides by Imidazoles and Pyrazoles: a Simple Route to Green Synthesis of Benzopyrone-Azole Hybrids and Their Evaluation As Α-Glucosidase Inhibitors

Andrii S. Myshko,Galyna P. Mrug,Svitlana P. Bondarenko,Kostyantyn M. Kondratyuk,Oleksandr L. Kobzar,Vladyslav M. Buldenko,Andriy V. Kozytskiy,Andriy I. Vovk,Mykhaylo S. Frasinyuk

RSC ADVANCESno. 38 (2024): 27809-27815

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In Silico Design and Experimental Validation of Novel Oxazole Derivatives Against Varicella Zoster Virus

Vasyl Kovalishyn,Oleksandr Severin,Maryna Kachaeva,Oleksandr Kobzar,Kathy A. Keith,Emma A. Harden,Caroll B. Hartline,Scott H. James,Andriy Vovk,Volodymyr Brovarets

MOLECULAR BIOTECHNOLOGYno. 4 (2024): 707-717

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In Silico, in Vitro and in Vivo Study of Substituted Imidazolidinone Sulfonamides As Antibacterial Agents

Diana Hodyna,Vasyl Kovalishyn,Maryna Kachaeva,Yurii Shulha,Anton Klipkov,Elena Shaitanova,Oleksandr Kobzar,Oleh Shablykin,Larysa Metelytsia

Chemistry & biodiversityno. 12 (2023)

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Inhibition of Xanthine Oxidase by Pyrazolone Derivatives Bearing a 4-(Furan-2-yl)benzoic Acid Moiety

Alona V. Beiko,Oleksandr L. Kobzar,Maryna V. Kachaeva,Stepan G. Pilyo,Vsevolod Yu. Tanchuk,Andriy I. Vovk

Žurnal organìčnoï ta farmacevtičnoï hìmìïno. 4 (2023): 27-35

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Design, Synthesis and Evaluation of the Anti-Breast Cancer Activity of 1,3-Oxazolo[4,5-d]pyrimidine and 1,3-Oxazolo[5,4-d]pyrimidine Derivatives

Yevheniia Velihina,Raey Gesese,Victor Zhirnov,Oleksandr Kobzar, Benjamin Bui,Stepan Pilyo,Andriy Vovk,Hai-Ying Shen,Volodymyr Brovarets

RSC medicinal chemistryno. 4 (2023): 692-699

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In Vitro Activity of Novel 4-Iminohydantoin Sulfamide Derivatives Against Human Cytomegalovirus

Victor Zhirnov,Oleh Shablykin,Svitlana Chumachenko,Yurii Kornii,Kathy A. Keith,Emma A. Harden,Caroll B. Hartline,Scott H. James,Oleksandr Kobzar,Vasyl Kovalishyn,Andriy Vovk,Volodymyr Brovarets

Chemical Papersno. 1 (2023): 133-140

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Synthesis and in Vitro Anticancer Potential of New Thiazole-Containing Derivatives of Rhodanine

Oleksandr V. Los, Vitalii O. Sinenko,Oleksandr L. Kobzar,Victor V. Zhirnov,Andriy I. Vovk,Volodymyr S. Brovarets

Chemistry of heterocyclic compoundsno. 6-7 (2023): 484-493

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Carboxylated Chalcones and Related Flavonoids As Inhibitors of Xanthine Oxidase

Oleksandr L. Kobzar, Alona V. Tatarchuk,Galyna P. Mrug,Svitlana P. Bondarenko,Bohdan A. Demydchuk,Mykhaylo S. Frasinyuk,Andriy I. Vovk

MEDICINAL CHEMISTRY RESEARCHno. 8 (2023): 1804-1815

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