基本信息
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Career Trajectory
Bio
My research is focused on molecular recognition in biocatalysis, enzyme inhibition and signal transduction. We study the interaction of ligands and proteins via X-ray crystallography, binding assays, kinetics as well as biophysical and spectroscopic techniques. A main aim is to characterize the molecular principles of interaction leading to specificity, catalysis as well as conformational changes such as domain motions. This information is used to understand the mode of action of enzymes, receptors and other proteins and also to apply it to structure-based rational design of novel biocatalysts and pharmacologically relevant protein inhibitors. In addition to experimental methods, computational tools are a key method to rationalize structure-function relationships as well as for enzyme or inhibitor design.
Research Interests
Papers共 210 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of medicinal chemistry (2024)
Biomoleculesno. 6 (2024): 640-640
Mianling Yang,Myoung Kyu Lee,Shenghua Gao,Letian Song, Hye-Yeon Jang, Inseong Jo, Chun-Chiao Yang,Katharina Sylvester,Chunkyu Ko,Shuo Wang, Bing Ye,Kai Tang, Junyi Li, Manyu Gu,Christa E Müller,Norbert Sträter,Xinyong Liu, Meehyein Kim,Peng Zhan
Advanced science (Weinheim, Baden-Wurttemberg, Germany)pp.e2404884-e2404884, (2024)
Angewandte Chemieno. 17 (2023)
Cell reportsno. 7 (2023): 112679-112679
Communications chemistryno. 1 (2023)
Journal of medicinal chemistryno. 23 (2023): 16426-16440
Research Square (Research Square) (2023)
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Author Statistics
#Papers: 210
#Citation: 8535
H-Index: 42
G-Index: 91
Sociability: 6
Diversity: 0
Activity: 2
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