Based on the experience from his thesis on time trends and population differences in acute myocardial infarction in Sweden, he built and was responsible for a local register of myocardial infarction in Stockholm County that was based on register linkages. He also, together with professor Torbjörn Ivert, developed a local register for thoracic surgery that was used in several publications and thesis work. In 2002, he joined a team working on epidemiology and Real World Evidence at AstraZeneca (AZ) Research & Development. During the years at AZ he was among other things Head of the European team in Epidemiology and helped building the Real World Evidence capability in the company, in particular in the Cardiovascular and Renal, Metabolic therapeutic area, to an industry leading position. He was also member of the scientific committee for large epidemiologic studies, in particular for diabetes, including the DISCOVER and the CVD REAL studies.