My laboratory is committed to understanding the mechanisms by which Mycobacterium tuberculosis causes Tuberculosis (TB). One in three people in the world are infected with this bacterium, resulting in approximately 4,000 deaths every day. My lab utilises modern molecular genomic technologies to identify the genetic requirements for M. tuberculosis to cause TB. This information is being translated into the development of new therapies and control measures for TB. Research within the group will fall largely into one of the following three themes: Essential Gene Identification in M. tuberculosis, Understanding Latency and Targeted Drug Development.