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Being a Catalan woman who barely spoke Swedish did not hinder Neus Visa from teaching at the Department of Molecular Biology and Functional Genomics of the Stockholm University and, with time, from mastering the Swedish language. Teaching accounts for only 25% of her professional life. The rest of her time is invested in trying to understand the role of RNA-related proteins. Neus Visa (Barcelona, 1962) has been living in Sweden for more than thirteen years. In spite of assuring that her process of adaptation to the Swedish way of life is never quite completed, her private life and her scientific career are closely bound to this Northern country.
She arrived in Sweden in 1992 with a postdoctorate scholarship at the Karolinska Institutet, known worldwide as the institution that appoints the laureates for the Nobel Prize of Medicine every year. She was connected with this institution for seven years, including a full year of maternity leave. As Neus Visa acknowledged, this measure allowed her to raise her daughter without breaking her professional career –this being one of the many advantages offered by this paradigmatic ‘Welfare State’ country.
Our Catalan researcher also sees important differences between Sweden and Spain, for example in the degree of internationalization. The great diversity of nationalities within the different scientific institutions of the country, says she, is a key aspect in the achievement of a dynamic, effective atmosphere at work. In this sense, she fully agrees with another three colleagues participating in the Science in Europe set of lectures organized jointly by Aula El País and the Esteve Foundation. The four of them shared their experience as Spanish researchers working in renowned European centers.
All four researchers also agreed in that the level of fundings assigned to science by their host countries is quite higher than ours. Nonetheless, while budgets assigned to research groups in Sweden are big, Dr. Visa nuanced that these fundings are decreasing in Sweden, as opposed to relevant improvements in Spain.
The differences, however, are still profound. A young researcher in Sweden may be offered 35,000 euros a year for the development of new projects. Much to the amazement of her (mostly Spanish) audience, Neus Visa considered that this quantity was modest –which went to prove that her process of adaptation is now complete and that she is closer to Sweden than to Spain.
Research
The research of the group aims at understanding the mechanisms by which RNA and RNA degradation by the exosome contribute to chromatin regulation and genome integrity. The organization of the DNA into chromatin and the maintenance of the integrity of the genome are essential biological processes, and research from many laboratories has provided knowledge about the proteins that are responsible for these processes. In recent years, we have learned that not only proteins but also RNAs play important roles in genome organization, regulation and repair. Indeed, eukaryotic genomes are transcribed to a much larger extent than previously anticipated, and different types of non-coding RNAs (ncRNAs) have been identified in the last decade. Some of these ncRNAs regulate chromatin structure and gene expression, and their biogenesis and turnover depend on the activity of the exosome. The exosome is a multiprotein complex that is responsible for the processing and degradation of many RNAs in eukaryotic cells. As part of our studies on the function of the exosome, we discovered unexpected links between the exosome, chromatin proteins and DNA repair factors, and this discovery prompted us to investigate the roles of the exosome in the maintenance of genome integrity. Our research addresses the following specific questions:
- the roles the exosome in the organization of the chromatin
- the importance of RNA synthesis and degradation at DNA double-strand breaks
In collaboration with the Östlund Farrants Group at MBW, we are also interested in understanding the crosstalk between transcription, chromatin structure and pre-mRNA processing, with focus on the mechanisms by which SWI/SNF regulates pre-mRNA processing.
We use the fruit fly (Drosophila melanogaster) as a model organism to study chromatin-associated ncRNAs and to investigate the regulation of pre-mRNA processing by SWI/SNF. We use mammalian cell systems for studies of DNA repair. We combine biochemistry, molecular biology and advanced cell biology, including high-throughput methods such as RNA-seq and ChIP-seq.
Our research provides knowledge about fundamental genetic processes. Furthermore, our work is interesting from a biomedical perspective. Novel strategies to treat human diseases, including cancer and neurological disorders, target chromatin regulatory pathways and DNA repair factors. The exosome itself has been linked to human diseases and proposed as a possible target for therapeutic intervention. Thus, understanding the mechanisms of chromatin regulation and exosome function is of outmost strategic relevance.
She arrived in Sweden in 1992 with a postdoctorate scholarship at the Karolinska Institutet, known worldwide as the institution that appoints the laureates for the Nobel Prize of Medicine every year. She was connected with this institution for seven years, including a full year of maternity leave. As Neus Visa acknowledged, this measure allowed her to raise her daughter without breaking her professional career –this being one of the many advantages offered by this paradigmatic ‘Welfare State’ country.
Our Catalan researcher also sees important differences between Sweden and Spain, for example in the degree of internationalization. The great diversity of nationalities within the different scientific institutions of the country, says she, is a key aspect in the achievement of a dynamic, effective atmosphere at work. In this sense, she fully agrees with another three colleagues participating in the Science in Europe set of lectures organized jointly by Aula El País and the Esteve Foundation. The four of them shared their experience as Spanish researchers working in renowned European centers.
All four researchers also agreed in that the level of fundings assigned to science by their host countries is quite higher than ours. Nonetheless, while budgets assigned to research groups in Sweden are big, Dr. Visa nuanced that these fundings are decreasing in Sweden, as opposed to relevant improvements in Spain.
The differences, however, are still profound. A young researcher in Sweden may be offered 35,000 euros a year for the development of new projects. Much to the amazement of her (mostly Spanish) audience, Neus Visa considered that this quantity was modest –which went to prove that her process of adaptation is now complete and that she is closer to Sweden than to Spain.
Research
The research of the group aims at understanding the mechanisms by which RNA and RNA degradation by the exosome contribute to chromatin regulation and genome integrity. The organization of the DNA into chromatin and the maintenance of the integrity of the genome are essential biological processes, and research from many laboratories has provided knowledge about the proteins that are responsible for these processes. In recent years, we have learned that not only proteins but also RNAs play important roles in genome organization, regulation and repair. Indeed, eukaryotic genomes are transcribed to a much larger extent than previously anticipated, and different types of non-coding RNAs (ncRNAs) have been identified in the last decade. Some of these ncRNAs regulate chromatin structure and gene expression, and their biogenesis and turnover depend on the activity of the exosome. The exosome is a multiprotein complex that is responsible for the processing and degradation of many RNAs in eukaryotic cells. As part of our studies on the function of the exosome, we discovered unexpected links between the exosome, chromatin proteins and DNA repair factors, and this discovery prompted us to investigate the roles of the exosome in the maintenance of genome integrity. Our research addresses the following specific questions:
- the roles the exosome in the organization of the chromatin
- the importance of RNA synthesis and degradation at DNA double-strand breaks
In collaboration with the Östlund Farrants Group at MBW, we are also interested in understanding the crosstalk between transcription, chromatin structure and pre-mRNA processing, with focus on the mechanisms by which SWI/SNF regulates pre-mRNA processing.
We use the fruit fly (Drosophila melanogaster) as a model organism to study chromatin-associated ncRNAs and to investigate the regulation of pre-mRNA processing by SWI/SNF. We use mammalian cell systems for studies of DNA repair. We combine biochemistry, molecular biology and advanced cell biology, including high-throughput methods such as RNA-seq and ChIP-seq.
Our research provides knowledge about fundamental genetic processes. Furthermore, our work is interesting from a biomedical perspective. Novel strategies to treat human diseases, including cancer and neurological disorders, target chromatin regulatory pathways and DNA repair factors. The exosome itself has been linked to human diseases and proposed as a possible target for therapeutic intervention. Thus, understanding the mechanisms of chromatin regulation and exosome function is of outmost strategic relevance.
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Victor Karlstrom,Eduardo A. Sagredo, Jordi Planells,Charlotte Welinder, Jennifer Jungfleisch, Andrea Barrera-Conde, Linus Engfors,Chammiran Daniel,Fatima Gebauer,Neus Visa,Marie Ohman
NUCLEIC ACIDS RESEARCH (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Sonia Jimeno,Rosario Prados-Carvajal,María Jesús Fernández-Ávila,Sonia Silva,Domenico Alessandro Silvestris,Martín Endara-Coll,Guillermo Rodríguez-Real,Judit Domingo-Prim,Fernando Mejías-Navarro,Amador Romero-Franco,Silvia Jimeno-González,Sonia Barroso,Valeriana Cesarini,Andrés Aguilera,Angela Gallo,Neus Visa,Pablo Huertas
Journal of cell scienceno. 7 (2020)
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#Papers: 99
#Citation: 3446
H-Index: 30
G-Index: 57
Sociability: 5
Diversity: 3
Activity: 9
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