Dr Kalia heads the Microcirculation Research Group which aims to investigate the role of the microcirculation in the pathophysiology of Ischaemia-Reperfusion (I/R) injury. Although she has significant experience in intravitally imaging a number of I/R injured organs including the small intestine, kidneys and liver, the current focus of her research is on investigating the role of the coronary microcirculation in myocardial infarction. To achieve this, her research team developed a novel methodology that allows the beating heart coronary microcirculation to be visualised in real-time in vivo. This method is being exploited to quantitate changes in thromboinflammatory events, microvascular leakage, tissue perfusion, functional capillary density and microvascular tone in response to myocardial I/R injury. Additional imaging modalities used include laser Doppler, laser speckle and infrared thermography.