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My group is focused on the molecular basis of liver diseases and disorders linked to intermediate filament (IF) gene mutations. We use biochemical, cell-based and in vivo approaches to identify potential disease targets and to understand their function and regulation. The major goal of our work is to promote the discovery of pharmacological agents that can slow or halt the progression of these diseases. Our liver-related studies linked liver injury susceptibility to the function of energy metabolism regulators, including the glycolytic enzyme GAPDH and the purine metabolizing enzymes nucleoside diphosphate kinase (NDPK) and ecto-5′-nucleotidase CD73. Current efforts in the lab are aimed at understanding the regulation and cell-specific functions of CD73 in various stages of liver disease, including fibrosis, cirrhosis and hepatocellular carcinoma. Our other interests are in the area of IFs and IF-related diseases. IF gene mutations are linked to a vast number of human pathologies, including skin fragility disorders, neuropathies, myopathies, liver diseases, metabolic dysfunctions, and premature aging syndromes. Effective treatments for diseases caused by IF gene mutations are lacking. Our long-term goal is to define the proteostasis network of IF proteins and to identify key features that are compromised by disease-causing or disease-promoting mutations. We are focused on various post-translational modifications (PTMs) and their cross-talk mechanisms.
Research Interests
Papers共 77 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of Biological Chemistryno. 7 (2024): 107402-107402
Cassandra L Phillips,Maryam Faridounnia,Rachel A Battaglia,Baggio A Evangelista,Todd J Cohen,Puneet Opal, Thomas W Bouldin,Diane Armao,Natasha T Snider
bioRxiv the preprint server for biology (2024)
Jean-Michel Paumier, James Zewe, Melissa R Pergande, Meghana Venkatesan,Eitan Israeli, Chiranjit Panja,Natasha Snider,Jeffrey Savas,Puneet Opal
crossref(2024)
Cancer Researchno. 17_Supplement_2 (2024)
CURRENT OPINION IN CELL BIOLOGY (2023)
bioRxiv : the preprint server for biology (2023)
Journal of the American Heart Association Cardiovascular and cerebrovascular diseaseno. 9 (2023)
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Author Statistics
#Papers: 77
#Citation: 2009
H-Index: 24
G-Index: 44
Sociability: 5
Diversity: 3
Activity: 22
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