Teumelsan Nardos

Departments of Medicinal Chemistry Hypertension, Ion Channels, Preclinical DMPK, and Chemistry Modeling, Merck Research Laboratories

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论文共 9 篇作者统计合作学者相似作者

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The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics

Harry R Chobanian,Yan Guo,Barbara Pio,Haifeng Tang,Nardos Teumelsan,Matthew Clements,Jessica Frie, Ronald Ferguson, Zach Guo,Brande S Thomas-Fowlkes,John P Felix,Jessica Liu,Martin Kohler,Birgit Priest,Caryn Hampton,Lee-Yuh Pai,Aaron Corona,Joseph Metzger,Vincent Tong,Elizabeth M Joshi,Ling Xu,Karen Owens,Kevin Maloney,Kathleen Sullivan,Alexander Pasternak

Bioorganic & Medicinal Chemistry Letters（2017）

引用11浏览0WOS引用

Discovery of a Potent and Selective ROMK Inhibitor with Improved Pharmacokinetic Properties Based on an Octahydropyrazino[2,1-C][1,4]oxazine Scaffold

Yuping Zhu,Reynalda K. de Jesus,Haifeng Tang,Shawn P. Walsh,Jinlong Jiang,Xin Gu,Nardos Teumelsan,Aurash Shahripour,Barbara Pio,Fa-Xiang Ding,Sookhee Ha,Birgit T. Priest,Andrew M. Swensen,Magdalena Alonso-Galicia,John P. Felix,Richard M. Brochu,Timothy Bailey,Brande Thomas-Fowlkes,Xiaoyan Zhou,Lee-Yuh Pai,Caryn Hampton,Melba Hernandez,Karen Owens,Juliann Ehrhart,Sophie Roy,Gregory J. Kaczorowski,Lihu Yang,Emma R. Parmee,Kathleen Sullivan,Maria L. Garcia,Alexander Pasternak

Bioorganic & medicinal chemistry letters（2016）

引用11浏览0WOS引用

Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure

Haifeng Tang,Yuping Zhu,Nardos Teumelsan,Shawn P Walsh,Aurash Shahripour,Birgit T Priest,Andrew M Swensen,John P Felix,Richard M Brochu,Timothy Bailey,Brande Thomas-Fowlkes,Lee-Yuh Pai,Caryn Hampton,Aaron Corona,Melba Hernandez,Joseph Metzger,Michael Forrest,Xiaoyan Zhou,Karen Owens,Vincent Tong,Emma Parmee,Sophie Roy,Gregory J Kaczorowski,Lihu Yang,Magdalena Alonso-Galicia,Maria L Garcia,Alexander Pasternak

ACS medicinal chemistry letters（2016）

引用21浏览0WOS引用

Differentiation of Romk Potency from Herg Potency in the Phenacetyl Piperazine Series Through Heterocycle Incorporation

Shawn P. Walsh,Aurash Shahripour,Haifeng Tang,Reynalda K. de Jesus,Nardos Teumelsan,Yuping Zhu,Jessica Frie,Birgit T. Priest,Andrew M. Swensen,Magdalena Alonso-Galicia,John P. Felix,Richard M. Brochu,Timothy Bailey,Brande Thomas-Fowlkes,Xiaoyan Zhou,Lee-Yuh Pai,Caryn Hampton,Melba Hernandez,Karen Owens,Juliann Ehrhart,Sophie Roy,Gregory J. Kaczorowski,Lihu Yang,Maria L. Garcia,Alexander Pasternak

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2016）

引用8浏览0WOS引用

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation

Shawn P. Walsh,Aurash Shahripour,Haifeng Tang,Nardos Teumelsan,Jessica Frie,Yuping Zhu,Birgit T. Priest,Andrew M. Swensen,Jessica Liu,Michael Margulis,Richard Visconti,Adam Weinglass,John P. Felix,Richard M. Brochu,Timothy Bailey,Brande Thomas-Fowlkes,Magdalena Alonso-Galicia,Xiaoyan Zhou,Lee-Yuh Pai,Aaron Corona,Caryn Hampton,Melba Hernandez, Ross Bentley,Jing Chen,Kashmira Shah,Joseph Metzger,Michael Forrest,Karen Owens,Vincent Tong,Sookhee Ha,Sophie Roy,Gregory J. Kaczorowski,Lihu Yang,Emma Parmee,Maria L. Garcia,Kathleen Sullivan,Alexander Pasternak

ACS medicinal chemistry letters（2015）

引用18浏览0WOS引用

Discovery And Sar Evolution Of Romk Inhibitor Sub-Classes Toward Identification Of Our Clinical Development Compound

Alexander Pasternak,Haifeng Tang,Reynalda De Jesus,Shawn Walsh,Aurash Shahripour,Yuping Zhu,Nardos Teumelsan,Lihu Yang,Emma Parmee,Birgit Priest,John Felix,Brande Thomas-Fowlkes,Swensen Andrew,Gregory Kaczorowski,Maria Garcia,Adam Weinglass,Magdelana Alonso-Galicia,Xiaoyan Zhou,Lee-Yuh Pai,Caryn Hampton, Jodie Kunkel,Olga Price,Melba Hernandez,Charlie Gill,Maya Dajee,Kashmira Shah,Joseph Metzger,Michael Forrest,James Ormes,Mengwei Hu,Karen Owens,Koppora Samuel,Randy Miller,Vincent Tong,Thomas Bateman,Sophie Roy,Kathleen Sullivan

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2015）

引用0浏览0引用

From Screening Impurity To Potent And Selective Romk Inhibitors - The Path To New Mechanism Diuretics

Haifeng Tang,Reynalda De Jesus,Shawn P. Walsh,Aurash Shahripour,Yuping Zhu,Nardos Teumelsan,Lihu Yang,Emma Parmee,Sander G. Mills,Birgit T. Priest,John P. Felix,Brande Thomas-Fowlkes,Andrew M. Swensen,Gregory J. Kaczorowski,Maria L. Garcia,Adam Weinglass, Magdalena Alonso-Galacia,Xiaoyan Zhou,Lee-Yuh Pai,Caryn Hampton,Olga Price,Melba Hernandez,Charles Gill,Kashmira Shah,Joseph Metzger, Mike Forrest,James Ormes,Mengwei Hu,Karen Owens,Koppara Samuel,Randy R. Miller,Vincent Tong,Sophie Roy,Kathleen Sullivan,Alexander Pasternak

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2014)

引用0浏览0引用

Discovery of Selective Small Molecule Romk Inhibitors As Potential New Mechanism Diuretics

Haifeng Tang,Shawn P. Walsh, Yan,Reynalda K. de Jesus,Aurash Shahripour,Nardos Teumelsan,Yuping Zhu,Sookhee Ha,Karen A. Owens,Brande S. Thomas-Fowlkes,John P. Felix,Jessica Liu,Martin Kohler,Birgit T. Priest,Timothy Bailey,Richard Brochu,Magdalena Alonso-Galicia,Gregory J. Kaczorowski,Sophie Roy,Lihu Yang,Sander G. Mills,Maria L. Garcia,Alexander Pasternak

ACS medicinal chemistry letters（2012）

引用44浏览0WOS引用

Discovery Of A New Class Of Small Molecule Romk Blockers For The Treatment Of Hypertension

Haifeng Tang,Yan Yan,Reynalda Dejesus,Nardos Teumelsan,Yuping Zhu,Shawn Walsh,Aurash Shahripour,Ha Sookhee,Karen Owens,Brande Thomas-Fowlkes,John Felix,Jessica Liu,Martin Kohler,Birgit Priest,Timothy Bailey,Richard Brochu,Maria Garcia,Gregory Kaczorowski,Magdalena Alonso-Galicia,Sophie Roy,Lihu Yang, Sandy G. Mills,Kathleen Sullivan,Alexander Pasternak

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2011)

引用0浏览0引用

作者统计

#Papers: 9

#Citation: 113

H-Index: 6

G-Index: 6

Sociability: 4

Diversity: 1

Activity: 0

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