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Age-associated changes in the adaptive immune system are complex and highly consequential for the health and wellbeing of older humans. What we have learned for the past decades are alterations of compositions of T and B cells and their functions with advance of age. However, the mechanisms underlying these age-related changes in lymphocytes are not fully understood. Our research interests are 1) to identify the key transcriptome and epigenetic changes that causes age-related reduced functions of CD8 T cells including both naïve and memory cells. We are applying the genomic and molecular techniques and methods including RNAseq, scRNAse, ATACseq and ChIPseq to analyze human and mouse T cells; 2) to determine the size of general and antigen-specific ab TCR repertoires and their changes with age. We have incorporated tetramer staining and cell sort to isolate antigen specific CD8 T cells for their repertoire and individual TCR structure and function analyses using deep sequencing and x-ray crystal structures; and 3) to elucidate the role of telomere and telomerase in regulation of lymphocyte proliferation and function in human longitudinal follow-up samples as well as genetically modified mouse models. Collectively, we hope to elucidate the mechanisms underlying age-associated changes in T cells.
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FRONTIERS IN IMMUNOLOGY (2024): 1360229-1360229
Takenao Koseki, Mayumi Teramachi, Minako Koga,Minoru S.H. Ko,Tomokazu Amano,Hong Yu,Misa Amano,Erica Leyder,Maria Badiola,Priyanka Ray,Jiyoung Kim, Akihiro C. Ko,
medRxiv (Cold Spring Harbor Laboratory) (2023)
biorxiv(2023)
NEJM evidenceno. 9 (2023)
Journal of Immunologyno. 1 (2023): 239.20-239.20
Ainslee J. Zou,Jiangyuan Li,Cecily Choy,Joseph Chen, Humza Hemani,Beverly Baptiste,Julia McKelvey,Denise Melvin, Jeannie Ruffolo,Linda Zukley,Tonya Wallace,Christopher Dunn,
Journal of Immunologyno. 1 (2023): 236.10-236.10
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Seminars in immunology (2023): 101843-101843
Alzheimer's & dementia : the journal of the Alzheimer's Associationno. 11 (2023): 4841-4851
Cecily Choy,Joseph Chen,Jiangyuan Li,D. Travis Gallagher,Jian Lu,Daichao Wu, Ainslee Zou,Humza Hemani,Beverly A. Baptiste, Emily Wichmann,Qian Yang, Jeffrey Ciffelo,
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