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个人简介
Our basic research program focuses on dysfunction of cortico-limbic-striatal circuits that subserve dysfunctional cognitive control, impulsivity and alterations in reward-related learning with relevance to drug addiction, depression, schizophrenia, and Tourette Syndrome. Our current studies examine how DA/PKA-regulated intracellular signaling and neurotrophin molecules within the prefrontal cortex, amygdala, and accumbens contribute to motivation, learning, and memory processes, including memory reconsolidation. Studies in monkeys have found long-lasting deficits in inhibitory control after repeated cocaine exposure and alterations in reward-related learning. We have recently developed a novel corticosterone model of depression and also examine sex differences in attention, motivation, and impulse control in rodents and underlying molecular alterations. Several addictive/abused drugs such as cocaine, amphetamine, PCP, THC, nicotine, and alcohol are examined using drug self-administration models. We use transgenic mouse models, intracerebral infusion techniques, and viral-vector mediated overexpression of targeted proteins in combination with sophisticated behavioral techniques in mice, rats, and monkeys.
研究兴趣
论文共 150 篇作者统计合作学者相似作者
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Cell Reportsno. 6 (2024): 114355-114355
BMJ OPENno. 4 (2024)
BMJ Openno. 4 (2024): e077390-e077390
ACTIVE LEARNING IN HIGHER EDUCATIONno. 1 (2024): 25-40
BMJ Openno. 4 (2024)
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2023)
Jane Taylor,Anne Roiko,Leanne Coombe, Sue Devine,John Oldroyd,Jonathan Hallett,Zoë Murray,Francis Nona,Condy Canuto, Dionne Amato Ali,Gemma Crawford, Tracy Gurnett
Australian and New Zealand journal of public healthno. 2 (2023): 100042-100042
The journal of neuroscience/The Journal of neuroscienceno. 3 (2022): 458-471
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作者统计
#Papers: 150
#Citation: 9291
H-Index: 53
G-Index: 95
Sociability: 6
Diversity: 3
Activity: 19
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