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The generation and differentiation of neurons and glial cells are dependent upon cell-cell interactions mediated by a wide variety of growth factors and cytokines. The laboratory is interested in receptor-mediated mechanisms that direct cell differentiation versus cell proliferation in the nervous system. A major goal is to identify the biochemical steps that provide specificity in NGF signaling. Control of cell survival and death by neurotrophins is dictated by an unusual transduction system consisting of two transmembrane receptors, the TrkA tyrosine kinase and the p75 neurotrophin receptor, a member of the TNF receptor superfamily. Members of the NGF family are responsible for neuronal cell survival by activating Trk tyrosine kinases. However, NGF can have the opposite effect, promoting a cell death signal through the p75 receptor. NGF can induce apoptosis of mature oligodendrocytes cultured from rat cerebral cortex. NGF binding to oligodendrocytes expressing the p75 receptor, but not TrkA, resulted in an increase c-jun kinase and caspase activity. Therefore, NGF has the ability of promoting cell survival and cell death in specific cell types through novel signaling mechanisms involving TrkA and p75 receptors. The structural and biochemical features of these two receptors are being defined together with their intracellular signaling mechanisms.
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论文共 444 篇作者统计合作学者相似作者
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Pernille B Thomassen,Alena Salasova,Hande Login, S Beel, Jeppe Tranberg-Jensen,Per Qvist,Peter Lund Ovesen,Stella Nolte,LN Nejsum,Moses V Chao,J Dasen, P Van Damme,Kasper Kjaer Sorensen,Claus Oxvig,Anders Nykjaer
bioRxiv (Cold Spring Harbor Laboratory) (2023)
M. C. Selles Japas, J. T. Fortuna, Y. P. Faria, L. Domett,B. M. Longo,R. C. Froemke,M. V. Chao,S. T. Ferreira
GLIA (2023): E267-E267
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GLIA (2023): E66-E66
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iScienceno. 4 (2023): 106545-106545
bioRxiv the preprint server for biology (2023)
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#Papers: 444
#Citation: 49864
H-Index: 114
G-Index: 219
Sociability: 7
Diversity: 0
Activity: 1
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