Miriam Ruth Heindl - Institute of Virology, Philipps-University

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Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors

Roman W. Lange, Konstantin Bloch,Miriam Ruth Heindl,Jan Wollenhaupt,Manfred S. Weiss,Hans Brandstetter,Gerhard Klebe,Franco H. Falcone, Eva Boettcher-Friebertshaeuser,Sven O. Dahms,Torsten Steinmetzer

CHEMMEDCHEM（2024）

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Distinct Negative-Sense RNA Viruses Induce a Common Set of Transcripts Encoding Proteins Forming an Extensive Network

Nina Hofmann,Marek Bartkuhn,Stephan Becker,Nadine Biedenkopf, Eva Boettcher-Friebertshaeuser,Karina Brinkrolf,Erik Dietzel,Sarah Katharina Fehling,Alexander Goesmann,Miriam Ruth Heindl, Simone Hoffmann,Nadja Karl, Andrea Maisner,Ahmed Mostafa, Laura Kornecki, Helena Mueller-Kraeuter, Christin Mueller-Ruttloff,Andrea Nist,Stephan Pleschka,Lucie Sauerhering,Thorsten Stiewe,Thomas Strecker,Jochen Wilhelm,Jennifer D. Wuerth,John Ziebuhr,Friedemann Weber, M. Lienhard Schmitz

JOURNAL OF VIROLOGY (2024)

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Front Cover: Fragment‐Based Design, Synthesis, and Characterization of Aminoisoindole‐Derived Furin Inhibitors (ChemMedChem 9/2024)

Roman W. Lange, Konstantin Bloch,Miriam Ruth Heindl,Jan Wollenhaupt,Manfred S. Weiss,Hans Brandstetter,Gerhard Klebe,Franco H. Falcone,Eva Böttcher‐Friebertshäuser,Sven O. Dahms,Torsten Steinmetzer

ChemMedChemno. 9 (2024)

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ACE2 Acts As a Novel Regulator of TMPRSS2-catalyzed Proteolytic Activation of Influenza A Virus in Airway Cells

Miriam Ruth Heindl, Anna-Lena Rupp,Marie Schwerdtner,Dorothea Bestle,Anne Harbig, Amy De Rocher,Luna C. Schmacke,Bart Staker,Torsten Steinmetzer,David A. Stein,Hong M. Moulton,Eva Boettcher-Friebertshaeuser

JOURNAL OF VIROLOGY（2024）

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The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin

Thuy Van Lam van,Miriam Ruth Heindl, Christine Schlutt, Eva Boettcher-Friebertshaeuser,Ralf Bartenschlager,Gerhard Klebe,Hans Brandstetter,Sven O. Dahms,Torsten Steinmetzer

ACS Medicinal Chemistry Letters（2021）

引用10浏览0WOS引用

TMPRSS2 and Furin Are Both Essential for Proteolytic Activation of SARS-CoV-2 in Human Airway Cells

Dorothea Bestle,Miriam Ruth Heindl,Hannah Limburg,Thuy Van Lam Van,Oliver Pilgram,Hong Moulton,David A. Stein,Kornelia Hardes,Markus Eickmann,Olga Dolnik,Cornelius Rohde,Hans-Dieter Klenk,Wolfgang Garten,Torsten Steinmetzer, Eva Boettcher-Friebertshaeuser

bioRxiv (Cold Spring Harbor Laboratory)（2020）

引用621浏览0WOS引用

621

TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets

Dorothea Bestle,Miriam Ruth Heindl,Hannah Limburg,Thuy Van Lam van,Oliver Pilgram,Hong Moulton,David A. Stein,Kornelia Hardes,Markus Eickmann,Olga Dolnik,Cornelius Rohde,Stephan Becker,Hans-Dieter Klenk,Wolfgang Garten,Torsten Steinmetzer,Eva Bottcher-Friebertshauser

bioRxivpp.1-33, (2020)

引用57浏览0引用

Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin

Thuy Van Lam Van,Teodora Ivanova,Kornelia Hardes,Miriam Ruth Heindl,Rory E. Morty, Eva Boettcher-Friebertshaeuser,Iris Lindberg,Manuel E. Than,Sven O. Dahms,Torsten Steinmetzer

ChemMedChem（2019）

引用26浏览0WOS引用

Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia

Tatiana V Kalymbetova,Balachandar Selvakumar,José Alberto Rodríguez-Castillo,Miša Gunjak,Christina Malainou,Miriam Ruth Heindl,Alena Moiseenko,Cho-Ming Chao,István Vadász,Konstantin Mayer,Jürgen Lohmeyer,Saverio Bellusci,Eva Böttcher-Friebertshäuser,Werner Seeger,Susanne Herold,Rory E Morty

JOURNAL OF PATHOLOGY（2018）

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