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As a structural biology lab, we are interested in understanding the mechanism of molecular machines and their roles in human diseases. Currently we focus on two systems, p97 / ubiquitination system, and vault. p97 is a central hub in cellular protein homeostasis. It is involved in several neurodegenerative diseases, and is also a cancer drug target. We want to gain insights into the molecular architectures of p97 in complex with various cofactor proteins and poly-ubiquitinated substrates. We are investigating the specificity of p97 towards ubiquitin chains with various topologies. Our findings will elucidate the molecular mechanism of human p97. Vault is the largest ribonuclear protein in many eukaryotes including human. It is a membraneless organelle. Despite the fact that vault has been studied for thirty years, its function remains elusive. Overexpression of major vault protein (MVP) correlates with drug resistance in cancer cells. However, the mechanism is completely unknown at the molecular level. We are investigating the structures of vault components and using proteomic and imaging techniques to address the molecular function of vault. There are two major techniques used in the lab: X-ray crystallography and cryo-electron microscopy.
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论文共 77 篇作者统计合作学者相似作者
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Matthew O. Ross,Yuan Xie, Ryan C. Owyang,Chang Ye, Olivia N. P. Zbihley,Ruitu Lyu, Tong Wu,Pingluan Wang,Olga Karginova,Olufunmilayo I. Olopade,Minglei Zhao,Chuan He
NATURE COMMUNICATIONSno. 1 (2024)
Nature Communicationsno. 1 (2024): 1-11
Nature communicationsno. 1 (2024): 5946-5946
Jane E Lodwick, Rong Shen,Satchal Erramilli,Yuan Xie, Karolina Roganowicz,Anthony A Kossiakoff,Minglei Zhao
bioRxiv : the preprint server for biology (2024)
Catherine L. Lawson,Andriy Kryshtafovych,Grigore D. Pintilie,Stephen K. Burley,Jiri Cerny,Vincent B. Chen,Paul Emsley,Alberto Gobbi,Andrzej Joachimiak,Sigrid Noreng,Michael G. Prisant,Randy J. Read,Jane S. Richardson,Alexis L. Rohou,Bohdan Schneider,Benjamin D. Sellers,Chenghua Shao, Elizabeth Sourial,Chris I. Williams,Christopher J. Williams, Ying Yang, Venkat Abbaraju,Pavel V. Afonine,Matthew L. Baker,Paul S. Bond,Tom L. Blundell,Tom Burnley,Arthur Campbell,Renzhi Cao,Jianlin Cheng,Grzegorz Chojnowski,K. D. Cowtan,Frank DiMaio,Reza Esmaeeli,Nabin Giri,Helmut Grubmueller,Soon Wen Hoh,Jie Hou,Corey F. Hryc,Carola Hunte,Maxim Igaev,Agnel P. Joseph,Wei-Chun Kao,Daisuke Kihara,Dilip Kumar,Lijun Lang, Sean Lin,Sai R. Maddhuri Venkata Subramaniya,Sumit Mittal,Arup Mondal,Nigel W. Moriarty,Andrew Muenks,Garib N. Murshudov,Robert A. Nicholls,Mateusz Olek,Colin M. Palmer,Alberto Perez,Emmi Pohjolainen,Karunakar R. Pothula,Christopher N. Rowley,Daipayan Sarkar,Luisa U. Schaefer,Christopher J. Schlicksup,Gunnar F. Schroeder,Mrinal Shekhar,Dong Si,Abhishek Singharoy,Oleg V. Sobolev,Genki Terashi,Andrea C. Vaiana,Sundeep C. Vedithi,Jacob Verburgt,Xiao Wang,Rangana Warshamanage,Martyn D. Winn,Simone Weyand,Keitaro Yamashita,Minglei Zhao,Michael F. Schmid,Helen M. Berman,Wah Chiu
Nature methods (2024)
Gabriel Carmona Rosas,Jingxian Li,Jayson J. Smith, Sibo Cheng, Elana Baltrusaitis,Wioletta I. Nawrocka,Minglei Zhao,Paschalis Kratsios,Demet Araç,Engin Özkan
bioRxiv (Cold Spring Harbor Laboratory) (2023)
NATURE CHEMICAL BIOLOGYno. 11 (2023): 1384-+
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#Papers: 77
#Citation: 3724
H-Index: 27
G-Index: 61
Sociability: 6
Diversity: 0
Activity: 1
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