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My research involves X-ray crystallographic studies of macromolecular assemblies and enzymes involved in DNA metabolism, such as helicase/primase, dihydrofolate reductase (DHFR) and DNA polymerase beta (polB). Past projects include construction of a crystallographic movie of DHFR, depicting loop and subdomain conformational movements during one turnover of substrate. I have also written a web server for treating anisotropy in X-ray crystallographic data sets.
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Matthew P Agdanowski,Roger Castells-Graells,Michael R Sawaya,Duilio Cascio,Todd O Yeates,Mark A Arbing
Acta crystallographica. Section F, Structural biology communicationsno. Pt 5 (2024): 107-115
Bryan D. Ryder, Elizaveta Ustyantseva,David R. Boyer,Ayde Mendoza-Oliva, Mikołaj I. Kuska,Paweł M. Wydorski, Paulina Macierzynska, Nabil Morgan,Michael R. Sawaya,Marc I. Diamond,Harm H. Kampinga,Lukasz A. Joachimiak
biorxiv(2024)
Justin E Miller, Matthew P Agdanowski, Joshua L Dolinsky,Michael R Sawaya,Duilio Cascio,Jose A Rodriguez,Todd O Yeates
Acta crystallographica. Section D, Structural biologyno. Pt 4 (2024): 270-278
Proceedings of the National Academy of Sciences of the United States of Americano. 41 (2023): e2300258120-e2300258120
Nature Communicationsno. 1 (2023): 1-18
Roger Castells-Graells,Kyle Meador,Mark A. Arbing,Michael R. Sawaya, Morgan Gee,Duilio Cascio, Emma Gleave,Judit E. Debreczeni,Jason Breed,Karoline Leopold, Ankoor Patel,Dushyant Jahagirdar,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 37 (2023)
Kyle Meador,Roger Castells-Graells, Roman Aguirre,Michael R. Sawaya,Mark A. Arbing, Trent Sherman,Chethaka Senarathne,Todd O. Yeates
biorxiv(2023)
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