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Dr. Irwin pioneered basic studies to show that activation of receptor dependent mechanisms in the brain (e.g., corticotropin releasing hormone) play a key role in the integration of the HPA, autonomic, and immune responses to stress. His clinical translational studies were among the first to demonstrate that b-adrenergic receptor mechanisms steered a reduction in anti-viral immunity and an increase inflammatory responses, and the role of these molecular pathways on infectious- and inflammatory disease pathogenesis in older adults, and in patients with depression, insomnia, cardiovascular disease, cancer, rheumatoid arthritis, and alcohol- and cocaine use disorders. His ongoing work is focused on the reciprocal interactions between the immune- and central nervous systems, and the role of sleep disturbance on the molecular and cellular inflammatory signaling pathways that influence depression- and physical health risk with a focus on cancer survivors and older adults. Dr. Irwin s research has broadly integrated data from laboratory animal studies, epidemiological studies, clinical naturalistic history- and prospective studies, experimental studies, and randomized controlled trials that have employed both behavioral- and mind-body approaches, which has resulted in publication of over 300 research articles and several books.
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论文共 128 篇作者统计合作学者相似作者
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Brain, behavior, & immunity - health (2023): 100670-100670
Current biology : CBno. 5 (2023): 998-+
PSYCHOLOGICAL MEDICINEno. 6 (2023): 2285-2295
Brain, behavior, & immunity - health (2023): 100588-100588
Research square (2023)
NPJ BREAST CANCERno. 1 (2022): 91-8
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