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Our lab is broadly interested in how intestinal microbes shape our immune system to promote both health and disease. Recently we discovered that a type of intestinal epithelial cell, called tuft cells, act as sentinels stationed along the lining of the gut. Tuft cells respond to microbes, including parasites, to initiate type 2 immunity, remodel the epithelium, and alter gut physiology. Surprisingly, these changes to the intestine rely on the same chemosensory pathway found in oral taste cells. Currently, we aim to 1) elucidate the role of specific tuft cell receptors in microbial detection. 2) To understand how protozoa and bacteria within the microbiota impact host immunity. 3) Discover how tuft cells modulate surrounding cells and tissue.
研究兴趣
论文共 22 篇作者统计合作学者相似作者
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IMMUNITYno. 6 (2024)
Frank A. Buquicchio,Raissa Fonseca,Patrick K. Yan, Fangyi Wang,Maximilien Evrard,Andreas Obers,Jacob C. Gutierrez, Colin J. Raposo,Julia A. Belk,Bence Daniel, Pirooz Zareie,Kathryn E. Yost,Yanyan Qi,Yajie Yin,Katherine F. Nico, Flora M. Tierney,Michael R. Howitt, Caleb A. Lareau,Ansuman T. Satpathy,Laura K. Mackay
Immunity (2024)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 23 (2023)
Journal of Allergy and Clinical Immunologyno. 3 (2022): 580-582
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#Papers: 22
#Citation: 8269
H-Index: 9
G-Index: 14
Sociability: 5
Diversity: 2
Activity: 46
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