During his time at Mayo, Dr Hutton’s team played a major role in determining the causes of Fronto-temporal Dementia with the discovery mutations in tau and progranulin and the mechanism by which these lead to neurodegeneration. His team developed key animal models that have underpinned much of the research on the role of tau in Alzheimer’s Disease over the past 10 years and he has published extensively on the mechanism by which tau causes neurodegeneration. Dr Hutton was awarded the Potamkin and Metlife Prizes in 2000 and 2001 respectively for his work on Alzheimer’s Disease and Fronto-temporal Dementia. He has published over 250 papers in peer reviewed journals and is a regular invited speaker at international conferences on Alzheimer’s Disease and related Neurodegenerative conditions.