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After a one-year postdoc in Washington D.C. at the Carnegie Institution Department of Terrestrial Magnetism where he discovered the existence of repeated sequences in the DNA of higher organisms in collaboration with Roy Britten, Michael returned to Cambridge and continued to focus on DNA-targeting molecules that distort its structure and function for his entire career. He was the first to show that intercalation by ethidium removes and reverses DNA supercoiling, after which he discovered the phenomenon of bis-intercalation by echinomycin and diacridines. His lab was one of three that simultaneously developed footprinting to determine ligand-binding sites on DNA, and went on to investigate the kinetics of binding as well as methods for making new antibiotics by directed biosynthesis. He also established the critical role of the 2-amino group of guanine in sequence recognition by small (and some large) molecules, and pioneered the use of atomic force microscopy to study the binding of drugs to DNA.
A world expert on the science of cancer, antibiotics, and drug interactions with DNA, Michael worked in the University of Cambridge's Department of Chemotherapy between 1965 and 2004. He held Guest Lecturer and Visiting Professor roles around the world during that time.
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Chemistry (Weinheim an der Bergstrasse, Germany)no. 21 (2024): e202400239-e202400239
Gemma Davison,Mathew P Martin,Shannon Turberville, Selma Dormen,Richard Heath,Amy B Heptinstall, Marie Lawson,Duncan C Miller,Yi Min Ng,James N Sanderson,Ian Hope,Daniel J Wood,
Daniel J Wood,J Daniel Lopez-Fernandez, Leanne E Knight,Islam Al-Khawaldeh, Conghao Gai,Shengying Lin,Mathew P Martin,Duncan C Miller,Céline Cano,Jane A Endicott,Ian R Hardcastle,Martin E M Noble,
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