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Our laboratory studies the structural biology of cell signaling and the actin cytoskeleton. Active areas of investigation include: 1) the structure and regulation of focal adhesion kinase, 2) the molecular mechanisms that drive recruitment and activation of Src-family kinases in T-cell activation, and 3) formin proteins and the mechanisms by which they carry out the regulated assembly of actin structures. Additionally, we are studying other signaling interactions that may be targets for development of anti-cancer drugs. These include b -catenin/Tcf-4 and the interaction of transcription factor activation domains with p300/CBP.
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ChemMedChempp.e202300343-e202300343, (2024)
Annual review of biochemistry (2024)
MOLECULAR PHARMACOLOGYno. 2 (2024): 97-103
Zhengnian Li, Wenchao Lu,Tyler S. Beyett,Scott B. Ficarro,Jie Jiang,Jason Tse, Audrey Yong-Ju Kim,Jarrod A. Marto,Jianwei Che,Pasi A. Janne,Michael J. Eck,Tinghu Zhang,
JOURNAL OF MEDICINAL CHEMISTRYno. 4 (2024): 2837-2848
Florian Wittlinger,Blessing C. Ogboo, Ekaterina Shevchenko,Tahereh Damghani,Calvin D. Pham,Ilse K. Schaeffner, Brandon T. Oligny, Surbhi P. Chitnis,Tyler S. Beyett, Alexander Rasch,Brian Buckley,Daniel A. Urul,
Communications Chemistryno. 1 (2024): 1-14
Nature Communicationsno. 1 (2023): 1-1
crossref(2023)
crossref(2023)
NATURE COMMUNICATIONSno. 1 (2023)
Jieun Son,Jaebong Jang,Tyler S. Beyett,Yoonji Eum,Heidi M. Haikala,Alyssa Verano,Mika Lin,John M. Hatcher, Nicholas P. Kwiatkowski,Pinar Ö. Eser,Michael J. Poitras,Stephen Wang,
crossref(2023)
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