Our interests cover aspects of membrane trafficking (endocytosis, autophagy, mitochondrial dynamics) and cell signaling with a view to understanding mechanisms that lead to pathologies such as cancer and neurodegeneration (Parkinson's Disease). We have a strong interest in the deubiquitylase (DUB) family of enzymes. We contribute to drug discovery programmes in this area together with other academic centres and industry partners. My laboratory is co-directed with Sylvie Urbé.