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Description of Clinical Expertise
Dr. Kayser is a practicing psychiatrist at the University of Pennsylvania School of Medicine, specializing in issues related to sleep and mental health.
Description of Research Expertise
Key words:
sleep, synapse, development, drosophila, psychiatry, behavior
Research interests:
We study how neural circuits give rise to complex behaviors, and how dysfunction of neural processes can cause mental illness. Our particular focus is in understanding how sleep -- a highly conserved behavior whose core function remains a mystery -- contributes to sculpting brain circuits during development and in other times of life.
Please visit www.kayserlab.com for more information
Research techniques:
drosophila genetics, behavioral assays, molecular biology, imaging approaches
Research summary:
Sleep abnormalities are pervasive across nearly all psychiatric disorders, and disrupted sleep early in life has been linked to mental illness in adulthood. Work in the Kayser Lab stands to connect this fundamental behavior – sleep – to both pathogenesis and treatment of neuropsychiatric disease. We primarily utilize the powerful genetic system Drosophila melanogaster (the fruit fly). The fly provides unparalleled neurogenetic approaches towards unraveling the neural logic of complex behaviors. In addition, genetic and molecular insights from Drosophila have repeatedly translated to higher organisms, even humans. The Kayser Lab is a "question-driven" lab. We use or develop any approaches necessary to further our understanding of biological processes that, when awry, contribute to neuropsychiatric disease.
Dr. Kayser is a practicing psychiatrist at the University of Pennsylvania School of Medicine, specializing in issues related to sleep and mental health.
Description of Research Expertise
Key words:
sleep, synapse, development, drosophila, psychiatry, behavior
Research interests:
We study how neural circuits give rise to complex behaviors, and how dysfunction of neural processes can cause mental illness. Our particular focus is in understanding how sleep -- a highly conserved behavior whose core function remains a mystery -- contributes to sculpting brain circuits during development and in other times of life.
Please visit www.kayserlab.com for more information
Research techniques:
drosophila genetics, behavioral assays, molecular biology, imaging approaches
Research summary:
Sleep abnormalities are pervasive across nearly all psychiatric disorders, and disrupted sleep early in life has been linked to mental illness in adulthood. Work in the Kayser Lab stands to connect this fundamental behavior – sleep – to both pathogenesis and treatment of neuropsychiatric disease. We primarily utilize the powerful genetic system Drosophila melanogaster (the fruit fly). The fly provides unparalleled neurogenetic approaches towards unraveling the neural logic of complex behaviors. In addition, genetic and molecular insights from Drosophila have repeatedly translated to higher organisms, even humans. The Kayser Lab is a "question-driven" lab. We use or develop any approaches necessary to further our understanding of biological processes that, when awry, contribute to neuropsychiatric disease.
研究兴趣
论文共 71 篇作者统计合作学者相似作者
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Alexandra E. Perlegos,Jaclyn Durkin,Samuel J. Belfer, Anyara Rodriguez,Oksana Shcherbakova, Kristen Park, Jenny Luong,Nancy M. Bonini,Matthew S. Kayser
bioRxiv : the preprint server for biology (2023)
Adil R Wani,Budhaditya Chowdhury, Jenny Luong, Gonzalo Morales Chaya, Krishna Patel,Jesse Isaacman-Beck,Orie Shafer,Matthew S Kayser,Mubarak Hussain Syed
bioRxiv : the preprint server for biology (2023)
SLEEPno. Supplement_1 (2023): A177-A177
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Naihua N. Gong, Hang Ngoc Bao Luong, An H. Dang,Benjamin Mainwaring,Emily Shields,Karl Schmeckpeper,Roberto Bonasio,Matthew S. Kayser
Current Biologyno. 18 (2022): 4025-4039.e3
Amy R. Poe, Lucy Zhu,Patrick D. McClanahan,Milan Szuperak,Ron C. Anafi,Andreas S. Thum,Daniel J. Cavanaugh,Matthew S. Kayser
bioRxiv (2022)
Sleep Medicine Reviews (2022): 101595-101595
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