Matt is responsible for leading the unit's Trial Conduct Methodology activities where he has a particular interest in improving clinical trial conduct, particularly around: the use of routinely-collected electronic health records (EHR) to support and run trials with Health Data Research UK; running trials with a view to regulatory use and submission; proportionate and efficient trial monitoring; adaptive and efficient designs for late-phase trials, including in uncommon conditions; clinical trial data sharing; communication of trial findings; function of trial oversight committees. His first involvement in methodology was the DAMOCLES project which set standards for (independent) Data Monitoring Committees and led to the widespread use of charters for trial committees. He is part of the faculty for UCL's regular 1-day course on Data Monitoring Committees in practice and has served as a member of IDMCs and TSCs for around 50 trials, often as chair, attending around 200 meetings. Matt teaches on the UCL Institute of Clinical Trials and Methodology's MSc in Clinical Trials and is currently supervising a 5 PhD students in areas of methodological priority.