Matthew Kennedy - Merck Research Laboratories

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论文共 178 篇作者统计合作学者相似作者

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Microglial Roles in Alzheimer's Disease: an Agent-Based Model to Elucidate Microglial Spatiotemporal Response to Beta-Amyloid

Catherine Weathered,Sophia Bardehle, Choya Yoon,Niyanta Kumar,Cheryl E. G. Leyns,Matthew E. Kennedy,Peter Bloomingdale,Elsje Pienaar

CPT Pharmacometrics &amp Systems Pharmacology（2024）

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Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss Through Mglur1 and AKAP150-anchored Calcineurin Signaling

Olga Prikhodko,Ronald K. Freund,Emily Sullivan,Matthew J. Kennedy,Mark L. Dell'Acqua

JOURNAL OF NEUROSCIENCEno. 37 (2024)

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Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors

Kaitlyn M. Logan, Will Kaplan,Vladimir Simov,Hua Zhou,Derun Li,Luis Torres,Gregori J. Morriello,John J. Acton,Barbara Pio,Yi-Heng Chen,Mitchell H. Keylor,Rebecca Johnson,Solomon D. Kattar,Ryan Chau, Xin Yan,Michael Ardolino,Cayetana Zarate,Karin M. Otte,Rachel L. Palte,Tina Xiong,Spencer E. McMinn,Shishi Lin,Santhosh F. Neelamkavil,Ping Liu,Jing Su,Laxminarayan G. Hegde,Janice D. Woodhouse, Lily Y. Moy, Paul J. Ciaccio, Jennifer Piesvaux, Matthias Zebisch, Clare Henry,John Barker,Harold B. Wood,Matthew E. Kennedy, Erin F. DiMauro,Matthew J. Fell,Peter H. Fuller

JOURNAL OF MEDICINAL CHEMISTRYno. 18 (2024): 16807-16819

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Mirna-Mediated Control of Gephyrin Synthesis Drives Sustained Inhibitory Synaptic Plasticity

Theresa M. Welle,Dipen Rajgor,Dean J. Kareemo,Joshua D. Garcia, Sarah M. Zych, Sarah E. Wolfe,Sara E. Gookin, Tyler P. Martinez, Mark L. Dell'Acqua, Christopher P. Ford,Matthew J. Kennedy,Katharine R. Smith

EMBO reportsno. 11 (2024): 5141-5168

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Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease

Journal of medicinal chemistryno. 21 (2023): 14912-14927

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Dually Innervated Dendritic Spines Develop in the Absence of Excitatory Activity and Resist Plasticity Through Tonic Inhibitory Crosstalk

Mason S. Kleinjan,William C. Buchta,Roberto Ogelman,In-Wook Hwang,Masaaki Kuwajima,Dusten D. Hubbard,Dean J. Kareemo,Olga Prikhodko,Samantha L. Olah,Luis E. Gomez Wulschner,Wickliffe C. Abraham,Santos J. Franco,Kristen M. Harris,Won Chan Oh,Matthew J. Kennedy

NEURON（2023）

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Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module

Shifeng Wang,Xu Chen,Lauren Crisman, Ximing Dou,Christina S. Winborn,Chun Wan, Harrison Puscher,Qian Yin,Matthew J. Kennedy,Jingshi Shen

Science advances（2023）

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Glucocerebrosidase Activity and Lipid Levels Are Related to Protein Pathologies in Parkinson’s Disease

Cheryl E. G. Leyns,Alice Prigent, Brenna Beezhold,Lihang Yao,Nathan G. Hatcher,Peining Tao,John Kang,EunRan Suh,Vivianna M. Van Deerlin,John Q. Trojanowski,Virginia M. Y. Lee,Matthew E. Kennedy,Matthew J. Fell,Michael X. Henderson

NPJ Parkinson's disease（2023）

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The Alzheimer’s Disease-Linked Protease BACE1 Modulates Neuronal IL-6 Signaling Through Shedding of the Receptor Gp130

Stephan A. Müller,Merav D. Shmueli,Xiao Feng,Johanna Tüshaus,Neele Schumacher,Ryan Clark,Brad E. Smith,An Chi,Stefan Rose-John,Matthew E. Kennedy,Stefan F. Lichtenthaler

Molecular neurodegeneration（2023）

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Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses

Samantha S. Olah,Dean J. Kareemo,William C. Buchta,Brooke L. Sinnen,Carley N. Miller,Hannah S. Actor-Engel,Sara E. Gookin,Christina S. Winborn,Mason S. Kleinjan,Kevin C. Crosby,Jason Aoto,Katharine R. Smith,Matthew J. Kennedy

Cell Reportsno. 11 (2023): 113331-113331

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