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Clarification of the molecular and cellular mechanisms of central and peripheral tolerance to pemphigus antigens
Pemphigus is a severe autoimmune bullous dermatosis caused by IgG autoantibodies against desmogleins. In a murine pemphigus model established by us, we were able to clarify the B and T cell aspects of the disease subsequent to the loss of immunological tolerance. In this project, we attempt to clarify how immunological tolerance to desmogleins is established under normal conditions, and also the processes leading to its disruption. Special focus will be placed on events in the thymus as well as on the dendritic cells in the skin.
Development of treatment for scarring alopecia using bioengineered human hair follicles
The goal of the present project is to bioengineer human hair follicles with maintenance of their full function and structure, for potential use in the treatment of permanent hair loss. We shall attempt to regenerate human hair follicles using a cell mixture of hair follicle bulge stem cells and dermal papilla cells with optimized hair-inductive capacity. The hair reorganization potency of the cell mixture will be assessed by hair reconstitution assays in vivo or using a 3-D culture system.
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Keitaro Fukuda,Yoshihiro Ito, Yuki Furuichi,Takeshi Matsui, Hiroto Horikawa,Takuya Miyano, Takaharu Okada, Mark van Logtestijn,Reiko J Tanaka, Atsushi Miyawaki,Masayuki Amagai
Nature communicationsno. 1 (2024): 4062-4062
Ryo Tanaka,Keiji Tanese,Yoshihiro Ito, Sakiko Takeuchi, Ari Morimoto, Kazuyo Sujino,Masayuki Amagai,Akiko Tanikawa
Clinical and experimental dermatology (2024)
Hodaka Hayabuchi, Yukiko Tokifuji,Hayato Takahashi,Masayuki Amagai,Akihiko Yoshimura,Shunsuke Chikuma
INTERNATIONAL IMMUNOLOGY (2024)
Ayumi Yamanishi,Noriko Ono, Asako Tsunoda,Yasuhiko Asahina,Takayuki Fusumae,Jun Yamagami, Noriyasu Sakai,Norito Ishii,Masayuki Amagai,Hayato Takahashi
Skin health and diseaseno. 2 (2024): e327-e327
Yukiko Tokifuji, Hodaka Hayabuchi,Takashi Sasaki,Mariko Hara-Chikuma,Keiji Hirota,Hayato Takahashi,Masayuki Amagai,Akihiko Yoshimura,Shunsuke Chikuma
ISCIENCEno. 1 (2024): 108646-108646
Kazuyo Sujino,Keiji Tanese,Yasuko Saito, Junko Kuramoto, Hideaki Iwazaki,Taiichiro Ida, Sadakazu Aiso,Nobuaki Imanishi,Hiroki Kajita,Keitaro Fukuda,Masayuki Amagai,Akiko Tanikawa
Journal of Investigative Dermatologyno. 5 (2023): S161-S161
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Masayuki Amagai,Keitaro Fukuda,Yoshihiro Ito,Yuki Furuichi, Toshinori Matsui, Hitomi Horikawa, Takuya Miyano,Takaharu Okada, Mark van Logtestijn,Reiko Tanaka,Atsushi Miyawaki
Research Square (Research Square) (2023)
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Journal of Investigative Dermatologyno. 5 (2023): S63-S63
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