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职业迁徙
个人简介
Mitochondrial research
Mitochondria are central to the conversion of nutrient energy into cellular energy by oxidative phosphorylation. Any chronic imbalance of mitochondrial energy homeostasis would impact cellular energy metabolism, resulting in metabolic diseases. A comprehensive quantitative assessment of mitochondrial bioenergetics is pivotal to identify defective mitochondrial mechanisms and pathways, thus to discover therapeutic drug targets to fight diseases such as obesity, diabetes and aging-related degeneration.
Therefore, our research goes beyond conventional correlation of gene products and function by directly assessing mitochondrial activity in the intact mitochondrion and cell. Mitochondrial oxygen consumption, membrane potential and reactive oxygen species production provide powerful readouts to demonstrate mitochondrial function and dysfunction (Jastroch et al. 2010, Essays in Biochemistry). We perform analyses on isolated mitochondria to identify intrinsic factors that alter mitochondrial energy transduction.
Cellular energy metabolism and consequences
We use novel sophisticated technologies (e.g. extracellular flux analyzer) to partition cellular oxygen consumption for analysis of mitochondrial efficiency in living cells. Recently, we reported on the interplay between mitochondrial dynamics and bioenergetics in pancreatic beta cells (Kabra et al. 2017, Diabetes), showing the influence of mitochondrial shape changes on insulin secretion. Our expertise is witnessed by many collaborative projects assisting colleagues to pinpoint defects in cellular energy metabolism.
Mitochondria are central to the conversion of nutrient energy into cellular energy by oxidative phosphorylation. Any chronic imbalance of mitochondrial energy homeostasis would impact cellular energy metabolism, resulting in metabolic diseases. A comprehensive quantitative assessment of mitochondrial bioenergetics is pivotal to identify defective mitochondrial mechanisms and pathways, thus to discover therapeutic drug targets to fight diseases such as obesity, diabetes and aging-related degeneration.
Therefore, our research goes beyond conventional correlation of gene products and function by directly assessing mitochondrial activity in the intact mitochondrion and cell. Mitochondrial oxygen consumption, membrane potential and reactive oxygen species production provide powerful readouts to demonstrate mitochondrial function and dysfunction (Jastroch et al. 2010, Essays in Biochemistry). We perform analyses on isolated mitochondria to identify intrinsic factors that alter mitochondrial energy transduction.
Cellular energy metabolism and consequences
We use novel sophisticated technologies (e.g. extracellular flux analyzer) to partition cellular oxygen consumption for analysis of mitochondrial efficiency in living cells. Recently, we reported on the interplay between mitochondrial dynamics and bioenergetics in pancreatic beta cells (Kabra et al. 2017, Diabetes), showing the influence of mitochondrial shape changes on insulin secretion. Our expertise is witnessed by many collaborative projects assisting colleagues to pinpoint defects in cellular energy metabolism.
研究兴趣
论文共 193 篇作者统计合作学者相似作者
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METABOLISM-CLINICAL AND EXPERIMENTAL (2024): 155709-155709
Molecular biology and evolutionno. 4 (2024)
Henver S Brunetta,Anna S. Jung, Fernando B Valdivieso-Rivera, Stepheny CC Zani, Vanessa Furino,Annelise Francisco, Pedro Vieira,Susanne Keipert,Martin Jastroch,Laurent O Martinez,Carlos Sponton,Roger F. Castilho,
crossref(2024)
Sajjad Khani,Hande Topel, Ronja Kardinal, Ana Rita Tavanez,Ajeetha Josephrajan,Bjork Ditlev Marcher Larsen,Michael James Gaudry,Philipp Leyendecker, Nadia Meincke Egedal, Aylin Seren Gueller, Natasa Stanic, Phillip M. M. Ruppert,
Experimental Cell Researchno. 1 (2023): 113536-113536
International journal of molecular sciencesno. 18 (2023): 13782-13782
Nature Metabolismno. 5 (2023): 722-723
D. Liskiewicz, Q. Zhang, C. S. Barthem,M. Jastroch,A. Liskiewicz, N. Khajavi,G. Grandl, C. Coupland,M. Kleinert,C. Garcia-Caceres,A. Novikoff, G. Maity,
Natureno. 7972 (2023): 42-43
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