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Prof. Hewison’s work focuses on different facets of vitamin D physiology, including classical skeletal effects and non-classical extra-skeletal effects. He has a particular interest in the interaction between vitamin D and the immune system, where antigen-presenting cells such as dendritic cells and macrophages synthesize active vitamin D (calcitriol) and also express the nuclear receptor for calcitriol (VDR). Vitamin D can therefore act as an endogenous regulator of both innate and adaptive immunity by enhancing antibacterial activity, and modulating antigen presentation and T lymphocyte function. Crucially these responses are highly dependent on the bioavailability of vitamin D, and Prof. Hewison has hypothesized that immune function is influenced by vitamin D status in humans. His group is using a variety of models to test this hypothesis including basic molecular and cell analyses, and vitamin D supplementation trials in human cohorts. A key objective of his work is to increase awareness of vitamin D-deficiency in the UK population.
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Elsevier eBookspp.155-187, (2024)
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Molly J Mead,Caroline A McWhorter, Megan D Rodgers,Myla D Ebeling,Judy R Shary,Mathew J Gregoski,Bruce W Hollis,Martin Hewison,Donna Johnson, Michael J Caplan,Carol L Wagner
Sreedhar Subramanian,Jonathan M Rhodes,Joseph M Taylor,Anna M Milan,Steven Lane,Martin Hewison,Rene F Chun,Andrea Jorgensen,Paul Richardson, Darshan Nitchingham,Joseph Aslan, Maya Shah,
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