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Dr Schneider is an internationally known leader in skeletal muscle excitation-contraction coupling, the series of steps whereby electrical depolarization of the normally inside negative muscle membrane potential initiates release of calcium ions (Ca2+) from their intracellular storage location, the muscle sarcoplasmic reticulum (SR), allowing Ca2+ ions bind to regulatory sites on muscle contractile filaments, which serves as a switch to permit contractile filament interaction, producing force development and muscle shortening. In pioneering work in collaboration with his post doc mentor Dr W.K. Chandler (Yale University), Dr Schneider made the first measurements of tiny electrical currents (charge displacement currents or channel “gating” currents) due to the redistribution of charged voltage sensor proteins within the muscle membrane. Such gating currents were previously predicted in the classic studies of Hodgkin and Huxley on voltage dependent channel activation underlying the action potential in nerve axons, and were first detected in any excitable cell membrane by Schneider and Chandler in skeletal muscle, where they control Ca2+ release from Ca2+ release channels in the spatially immediately adjacent SR membrane. Analogous gating currents were subsequently identified by other groups for gating voltage dependent Na+, K+ and Ca2+ channels in other excitable cells.
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biorxiv(2024)
Georgios Makridis,Tim Reese,Zoltan S. Zadori,Anna I. Suling,Maria Stark, Katja Horling, Roland Bruening,Martin A. Schneider, Michael Beumer,Karl J. Oldhafer
HPBno. 1 (2024): 91-101
Journal of visualized experiments : JoVE (2023)
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncologyno. 11 (2023): 106977-106977
European Journal of Surgical Oncologyno. 9 (2023): 106948-106948
BJS OPENno. 6 (2023)
American Journal of Physiology-heart and Circulatory Physiologyno. 5 (2023): H598-H609
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