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个人简介
Martin Eilers is professor of biochemistry and molecular biology at the University of Würzburg in Germany. After a Ph.D. at the university of Basel, he joined Michael Bishop’s laboratory at the UCSF, where he started working on Myc by generating MycER chimeric molecules, which are widely used as tools to study Myc and N-Myc proteins. Since then, his work focuses on the function and regulation of human Myc proteins. One focus of his recent work is the question of how proteasomal turnover of Myc proteins is coupled to the transcriptional activities. His work on neuroblastoma started from gene expression studies that identified a gene expression profile associated with MYCN amplification. An shRNA screen of these genes identified Aurora-A as being essential for growth of MYCN-amplified cells. The subsequent molecular analysis showed that Aurora-A and N-Myc form a complex that stabilizes N-Myc. Importantly, the complex can be targeted using small molecule inhibitors, leading to degradation of N-Myc and also, for some inhibitors, Aurora-A. In his presentation, Martin will discuss new insights into the composition, the structure and the function of the Aurora-A/N-Myc and Aurora-A/c-Myc complexes and will discuss implications for a targeted therapy.
研究兴趣
论文共 342 篇作者统计合作学者相似作者
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Markus Dehmer,Peter Gallant,Steffi Herold,Giacomo Cossa, Francesca Conte, Jan Koster,Florian Sauer,Christina Schuelein-Voelk,Carsten P. Ade,Raphael Vidal,Caroline Kisker,Rogier Versteeg,Petra Beli,Seychelle Vos,Martin Eilers,Gabriele Buechel
biorxiv(2024)
Nature communicationsno. 1 (2024)
Dimitrios Papadopoulos,Stefanie Anh Ha,Daniel Fleischhauer,Leonie Uhl,Timothy J. Russell,Ivan Mikicic,Katharina Schneider, Annika Brem, Omkar Rajendra Valanju,Giacomo Cossa,Peter Gallant,Christina Schuelein-Voelk,Hans Michael Maric,Petra Beli, Gabriele Bu,Seychelle M. Vos,Martin Eilers
MOLECULAR CELLno. 11 (2024)
Laura Grunewald,Lena Andersch,Konstantin Helmsauer,Silke Schwiebert,Anika Klaus,Anton G. Henssen, Teresa Straka,Marco Lodrini, Sebastian G. Wicha,Steffen Fuchs,Falk Hertwig,Frank Westermann,Alice Vitali, Carlotta Caramel,Gabriele Büchel,Martin Eilers,Kathy Astrahantseff,Angelika Eggert,Uta E. Höpken,Johannes H. Schulte,Thomas Blankenstein,Kathleen Anders,Annette Künkele
biorxiv(2024)
Raphael Vidal,Eoin Leen,Steffi Herold, Mareike Müller,Daniel Fleischhauer,Christina Schülein-Völk,Dimitrios Papadopoulos, Isabelle Röschert,Leonie Uhl,Carsten P Ade,Peter Gallant,Richard Bayliss,Martin Eilers,Gabriele Büchel
eLife (2024)
Markus Vogt, Nevenka Dudvarski Stankovic, Yiliam Cruz Garcia, Julia Hofstetter, Katharina Schneider, Filiz Kuybu, Theresa Hauck,Bikash Adhikari, Anton Hamann, Yamila Rocca, Lara Grysczyk, Benedikt Martin, Anneli Gebhardt-Wolf, Armin Wiegering, Markus Diefenbacher, Georg Gasteiger, Stefan Knapp, Dieter Saur,Martin Eilers, Mathias Rosenfeldt, Florian Erhard, Seychelle M. Vos, Elmar Wolf
GUT (2024)
Science immunologyno. 94 (2024)
biorxiv(2024)
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作者统计
#Papers: 339
#Citation: 28255
H-Index: 84
G-Index: 165
Sociability: 8
Diversity: 0
Activity: 2
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