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职业迁徙
个人简介
My laboratory studies mitochondrial and cellular production of reactive oxygen species and regulation of
oxidative phosphorylation. To investigate ROS production we have established the specific sites and regulation
of superoxide and hydrogen peroxide generation in the electron transport chain using novel endogenous
reporters and improved fluorescence methods. Using high-throughput screening we have identified novel
suppressors of ROS formation that do not inhibit energy metabolism, and are using them to probe and modulate
mitochondrial ROS production in situ in cells and in biochemical and behavioral fly and mouse models. To
investigate cellular regulation of mitochondrial oxidative phosphorylation, we have established fully quantitative
fluorescence microscopy measurements of plasma membrane and mitochondrial membrane potential, and
several conventional variables, and are improving the use of extracellular flux analysis on the Seahorse XF for
quantitative assay of the rates of ATP production by oxidative phosphorylation and glycolysis. Together, these
approaches are aimed at elucidating mitochondrial function in situ and the relationships between oxidative
phosphorylation and radical production in signaling pathways, aging and pathology.
研究兴趣
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#Papers: 452
#Citation: 43245
H-Index: 106
G-Index: 198
Sociability: 7
Diversity: 1
Activity: 1
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