基本信息
views: 37
Career Trajectory
Bio
ACADEMIC INTERESTS
The main research interest of our laboratory group is to examine the genetic control of autoimmune diseases to gain a better understanding of the mechanisms by which immune tolerance is broken. A major focus of our lab group is a human autoimmune syndrome called Autoimmune Polyglandular Syndrome Type 1 (APS1 or APECED), which is classically manifested by an autoimmune attack directed at multiple endocrine organs. This disease is inherited in a monogenic autosomal recessive fashion and the defective gene has been identified and is called Aire (for autoimmune regulator). Aire knockout mice, like their human counterparts, develop an autoimmune disease that is targeted to multiple organs. Through the use of the mouse model we, along with others, have determined that Aire plays an important role in immune tolerance by promoting the expression of many self proteins in specialized antigen presenting cells in the thymus called medullary epithelial cells (mTEC’s).
Recently, we have determined that this process is not only critical in the thymus, but also in peripheral lymphoid organs. Current studies in the lab are directed at further understanding the relative contribution of specialized Aire-expressing cells to immune tolerance in multiple autoimmune disease models. In addition to these ongoing studies, our laboratory is also interested the pathogenesis of autoimmune diabetes and in developing other models of autoimmune disease by using transgenic, knockout, and knock-in approaches.
The main research interest of our laboratory group is to examine the genetic control of autoimmune diseases to gain a better understanding of the mechanisms by which immune tolerance is broken. A major focus of our lab group is a human autoimmune syndrome called Autoimmune Polyglandular Syndrome Type 1 (APS1 or APECED), which is classically manifested by an autoimmune attack directed at multiple endocrine organs. This disease is inherited in a monogenic autosomal recessive fashion and the defective gene has been identified and is called Aire (for autoimmune regulator). Aire knockout mice, like their human counterparts, develop an autoimmune disease that is targeted to multiple organs. Through the use of the mouse model we, along with others, have determined that Aire plays an important role in immune tolerance by promoting the expression of many self proteins in specialized antigen presenting cells in the thymus called medullary epithelial cells (mTEC’s).
Recently, we have determined that this process is not only critical in the thymus, but also in peripheral lymphoid organs. Current studies in the lab are directed at further understanding the relative contribution of specialized Aire-expressing cells to immune tolerance in multiple autoimmune disease models. In addition to these ongoing studies, our laboratory is also interested the pathogenesis of autoimmune diabetes and in developing other models of autoimmune disease by using transgenic, knockout, and knock-in approaches.
Research Interests
Papers共 228 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Mark C. Anderson, Fiona Harley, Eduardo Almaraz,Nicholas M. Moore,Alan Landay,Mary Rodgers,Gavin A. Cloherty
Gastroenterologyno. 5 (2024): S-1604
Journal of hepatology (2024): S775-S775
Rachel S. Carling, Katy Hedgethorne,Anupam Chakrapani,Patricia L. Hall,Nick Flynn, Toby Greenfield,Stuart J. Moat, Joshua Ssali,Lynette Shakespeare, Nazia Taj,Teresa H. Y. Wu,Mark Anderson, Arunabha Ghosh,Hugh Lemonde,Germaine Pierre,Mark Sharrard, Sreevidya Sreekantam,James R. Bonham
INTERNATIONAL JOURNAL OF NEONATAL SCREENINGno. 1 (2024)
bioRxiv : the preprint server for biology (2023)
John V. Pluvinage,Thomas Ngo,Christopher M. Bartley,Aaron Bodansky,Bonny D. Alvarenga,Kelsey C. Zorn,Camille Fouassier,Colin Zamecnik,Adrian McCann,Trung Huynh,Weston Browne,Asritha Tubati,Sravani Kondapavulur,Mark S. Anderson,Ari J. Green,Ralph Green,Vanja Douglas,Martineau Louine,Bruce Cree,Stephen Hauser,William Seeley,Brandon B. Holmes,James A. Wells,Serena Spudich,Shelli Farhadian,Prashanth Ramachandran,Leslie Gillum,Chadwick M. Hales,Bryan Smith,Avindra Nath,Gina Suh,Eoin P. Flanagan,Jeffrey M. Gelfand, Joseph L. DeRisi,Samuel J. Pleasure,Michael R. Wilson
medRxiv (Cold Spring Harbor Laboratory) (2023)
Kristen Lavelle,Chester E. Chamberlain,Mark S. Anderson,Michael German,Angel Nip,Stephen E. Gitelman
Journal of the Endocrine Societyno. Supplement_1 (2023)
Regular and Young Investigator Award Abstracts (2023)
HEPATOLOGY COMMUNICATIONSno. 4 (2023)
Load More
Author Statistics
#Papers: 228
#Citation: 7389
H-Index: 36
G-Index: 82
Sociability: 8
Diversity: 0
Activity: 2
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn