Mark has published more than 500 original papers, reviews and book chapters, and 15 books. His research concerns several aspects of development and health, ranging from how the environment before and after birth affects the risk of chronic disease – such as cardiovascular and chronic lung disease, diabetes and obesity – to population studies aimed at the early identification of risk, so that timely preventative interventions can be made. The group are exploring the epigenetic processes which relate to such risks, and which may serve as valuable early life biomarkers. His Institute works on these problems in both developed and developing countries in many parts of the world. Mark is particularly interested in the links between medical science and society and was a founder member of the Wellcome Trust’s Sci-Art panel. He is much involved in educational projects to promote health literacy in school students and was a one of the founders of LifeLab – a purpose built classroom and laboratory in the hospital which has now engaged more than 11,000 adolescents from the Wessex region in the science behind health messages. He is very active in the public understanding of science and in explaining how evolutionary thinking applies to human biology and medicine. His recent popular science books include Mismatch – the lifestyle diseases timebomb (2006) which is translated into Mandarin, Portuguese and German, Principles of Evolutionary Medicine 2nd Edn 2015 and Fat, Fate & Disease (2012), all published by OUP and Ingenious: the unintended consequences of human innovation (2019, Harvard University Press).