Research interests Mario works on integrated assessment of sustainability issues. Using concepts from complex systems theory, he has developed an innovative scientific approach: Multi-Scale Integrated Analysis of Societal and Ecosystem Metabolism (MuSIASEM). MuSIASEM integrates biophysical and socioeconomic variables across multiple hierarchical scales, thus establishing a link between the metabolism of socio-economic systems and potential constraints of the natural environment. MuSIASEM allows the use of integrated sets of indicators that can be chosen "à la carte" by social actors in relation to multiple criteria of performance. Recent research has focused on the analysis of energy systems and energy scenarios and directives (projects EUFORIE, NETEP, PARTICIPIA), food systems (GLAMUR), and the nexus between energy, food, and water in relation to sustainable development goals (MAGIC). Key words Multi-Criteria Analysis of Sustainability; Integrated Assessment of Scenarios and Technological changes; Energy Analysis; Biocomplexity and Sustainability; Multi-Scale Integrated Analysis of Societal and Ecosystem Metabolism; Science for Governance.