Manuel Izquierdo

NANOIMMUNOLOGY. Exosomes are nanovesicles formed by inward budding of the limiting membrane of late endosomes.The exosomes accumulate into multivesicular bodies (MVBs). The stimulation of cells induces the fusion ofthe MVBs with the plasma membrane and exosome secretion. Our aims:1) To gain insights into the mechanisms by which T lymphocytes control the polarised traffic of MVBs and the secretion of exosomes. 2) To establish the role of proapoptotic exosomes in cytotoxicity by T lymphocytes .