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个人简介
Prior to 1980 the main focus of my work was developing novel routes to the synthesis of heterocyclic compounds. This is reflected in publications from the mid 1960s which elaborate on the chemistry of cyclic and acyclic systems with NNN bonds (1,2,3-triazines and 1,3-disubstituted triazenes) as well as bicyclic systems with bridgehead N atoms. All the early original work was published in esteemed mainstream chemistry journals especially J. Chem. Soc., Perkin Trans. 1. The focus of my work since 1980 has been the identification of what, I would assert, are the most precious commodities in drug discovery cancer research: novel molecules with novel biological properties. Through my familiarity with the literature of chemistry, cancer biology and pharmacology, I have developed antennae attuned to recognise what are potentially cunning molecules. (Note: what to other scientific constituencies might be more imaginative and stunning molecules derived from natural product scaffolds may not be optimal for the purpose in hand.) In the special context of a relatively small research group, the real scientific elegance of our work has derived from inventing molecules with three qualities: ease of synthesis; ability to perturb a biological mechanism not previously challenged in clinical trials; and pharmaceutical robustness. This is reflected in a changing emphasis in publications after 1980 to include journals such as Biochemistry, Cancer Research and J. Medicin. Chem. which publish interdisciplinary studies spanning the chemical, physical and biological sciences.
研究兴趣
论文共 203 篇作者统计合作学者相似作者
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Boon Shing Tan, Kai Hung Tiong, Ashwin Muruhadas, Nirmal Randhawa, Heng Lungh Choo,Tracey D. Bradshaw,Malcolm F. G. Stevens, Chee‐Onn Leong
openalex(2023)
European Journal of Medicinal Chemistry (2023): 115507-115507
Boon Shing Tan, Kai Hung Tiong, Ashwin Muruhadas, Nirmal Randhawa, Heng Lungh Choo,Tracey D. Bradshaw,Malcolm F. G. Stevens, Chee‐Onn Leong
openalex(2023)
RSC chemical biologyno. 10 (2023): 736-741
Boon Shing Tan, Kai Hung Tiong, Ashwin Muruhadas, Nirmal Randhawa, Heng Lungh Choo,Tracey D. Bradshaw,Malcolm F. G. Stevens, Chee‐Onn Leong
openalex(2023)
Boon Shing Tan, Kai Hung Tiong, Ashwin Muruhadas, Nirmal Randhawa, Heng Lungh Choo,Tracey D. Bradshaw,Malcolm F.G. Stevens, Chee-Onn Leong
crossref(2023)
Boon Shing Tan, Kai Hung Tiong, Ashwin Muruhadas, Nirmal Randhawa, Heng Lungh Choo,Tracey D. Bradshaw,Malcolm F. G. Stevens, Chee‐Onn Leong
openalex(2023)
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作者统计
#Papers: 203
#Citation: 5801
H-Index: 36
G-Index: 69
Sociability: 6
Diversity: 0
Activity: 0
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