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As an independent investigator, Dr. Whitman has focused on signals that control tissue specification and remodeling in normal embryogenesis and disease pathogenesis. In exploring the role of TGFß ligand in early embryonic specification, the Whitman lab identified the first Smad-interacting transcription factor, FAST-1, and established that FAST-1 has a central role in the regulation of early developmental patterning by TGFß ligands. More recent work in the lab has established the mechanism of action of the small molecule Halofuginone as a therapeutic for the treatment of pathological tissue remodeling associated with chronic inflammation and fibrosis. The discovery of the first secreted tyrosine kinase, VLK, in the lab has established a new mechanism for the regulation of matrix remodeling that is a major area of interest in the lab. While the experimental approach of the lab is to understand basic molecular mechanisms that regulate tissue remodeling, Dr. Whitman is also actively involved in the application of this understanding of molecular mechanisms to the development of new approaches to the treatment of diseases, including autoimmune disease, fibrosis, and arthritis.
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Nature communicationsno. 1 (2022)
David E. Maridas,Laura Gamer,Emily R. Moore, Annemiek M. Doedens,Yunqing Yu,Andreia Ionescu,Leila Revollo,Malcolm Whitman,Vicki Rosen
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#Papers: 127
#Citation: 14137
H-Index: 50
G-Index: 96
Sociability: 6
Diversity: 3
Activity: 5
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