基本信息
浏览量:45
职业迁徙
个人简介
The human genome is composed of ~3 billion base pairs of DNA. In order to grow, a human cell must precisely duplicate this entire genome each cell cycle and continuously protect it from damage or modification. Defects in DNA replication or repair result in higher rates of mutation, chromosome instability and have a direct role in a number of human diseases such as contributing to the development of cancer or causing genetic diseases such as Fragile X and Xeroderma Pigmentosum. Replication protein A (RPA) is a multi-functional, single-stranded DNA-binding protein. RPA is essential for DNA replication, DNA repair, recombination and coordination of the cellular response to DNA damage. RPA is composed of six structurally conserved DNA binding domains that are distributed in three subunits. The functions of these domains are poorly understood. RPA is also phosphorylated during S-phase and in response to DNA damage. Recent studies have shown that RPA hyper-phosphorylation modulates RPA activity and plays a role in the cellular response to DNA damage; however, the mechanism of this regulation is also poorly understood. Our current research focuses on utilizing a combination of in vitro and in vivo approaches to define functions of the domains of RPA and understanding the role of RPA in regulating cellular DNA metabolism. We are using molecular approaches to generate specific mutant forms of RPA. Biochemical and structural analyses are used to define the interactions of RPA with the different DNA substrates and protein complexes. We have also have recently established a system that uses RNAi and plasmid directed expression of exogenous genes to examine the activity of wild-type and mutant RPA genes in human cells. These studies will lead to a better understanding of the molecular mechanisms of cellular DNA metabolism and will contribute to developing new treatments for diseases associated with defects in DNA repair or replication.
研究兴趣
论文共 108 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Onyekachi Ononye, Sneha Surendran, Olivia K. Howald, Athena Kantartzis-Petrides,Matthew R. Jordan,Diana Ainembabazi,Marc S. Wold,John J. Turchi,Lata Balakrishnan
crossref(2024)
Terence Gall-Duncan,Jennifer Luo,Carla-Marie Jurkovic,Laura A. Fischer,Kyota Fujita,Amit L. Deshmukh,Rachel J. Harding,Stephanie Tran,Mustafa Mehkary,Vanessa Li,David E. Leib,Ran Chen,Hikari Tanaka,Amanda G. Mason,Dominique Levesque,Mahreen Khan,Mortezaali Razzaghi,Tanya Prasolava,Stella Lanni,Nozomu Sato,Marie-Christine Caron,Gagan B. Panigrahi,Peixiang Wang,Rachel Lau,Arturo Lopez Castel,Jean-Yves Masson,Lynette Tippett,Clinton Turner,Maria Spies,Albert R. La Spad,Eric I. Campos,Maurice A. Curtis,Francois-Michel Boisvert,Richard L. M. Faull,Beverly L. Davidson,Masayuki Nakamori,Hitoshi Okazawa,Marc S. Wold,Christopher E. Pearson
Cellno. 22 (2023): 4898-4919.e25
Terence Gall-Duncan,Jennifer Luo,Carla-Marie Jurkovic,Laura A. Fischer,Kyota Fujita,David E. Leib,Vanessa Li,Rachel J. Harding,Stephanie Tran,Ran Chen,Hikari Tanaka,Amit L. Deshmukh,Amanda G. Mason,Dominique Lévesque,Mahreen Khan,Stella Lanni,Nozomu Sato,Marie-Christine Caron,Jean-Yves Masson,Gagan B. Panigrahi,Tanya Prasolava,Peixiang Wang,Rachel Lau,Lynette Tippett,Clinton Turner,Albert R. La Spada,Eric I. Campos,Maurice A. Curtis,François-Michel Boisvert,Richard L.M. Faull,Beverly L. Davidson,Hitoshi Okazawa,Marc S. Wold,Christopher E. Pearson
bioRxiv (Cold Spring Harbor Laboratory)no. 22 (2022): 4898-+
Richa Sharma,Sushree S. Sahoo,Masayoshi Honda,Sophie L. Granger,Charnise Goodings, Louis Sanchez,Axel Kunstner,Hauke Busch,Fabian Beier,Shondra M. Pruett-Miller,Marcus B. Valentine,Alfonso G. Fernandez,Ti-Cheng Chang,Vincent Geli,Dmitri Churikov,Sandrine Hirschi,Victor B. Pastor,Melanie Boerries,Melchior Lauten,Charikleia Kelaidi,Megan A. Cooper,Sarah Nicholas,Jill A. Rosenfeld,Sophia Polychronopoulou,Caroline Kannengiesser,Carole Saintome,Charlotte M. Niemeyer,Patrick Revy,Marc S. Wold,Maria Spies,Miriam Erlacher,Stephane Coulon,Marcin W. Wlodarski
Masayuki Nakamori,Gagan B. Panigrahi,Stella Lanni,Terence Gall-Duncan,Hideki Hayakawa, Hana Tanaka,Jennifer Luo,Takahiro Otabe,Jinxing Li,Akihiro Sakata,Marie-Christine Caron,Niraj Joshi,Tanya Prasolava, Karen Chiang,Jean-Yves Masson,Marc S. Wold,Xiaoxiao Wang,Marietta Y. W. T. Lee,John Huddleston, Katherine M. Munson,Scott Davidson,Mehdi Layeghifard,Lisa-Monique Edward,Richard Gallon,Mauro Santibanez-Koref,Asako Murata,Masanori P. Takahashi,Evan E. Eichler,Adam Shlien,Kazuhiko Nakatani,Hideki Mochizuki,Christopher E. Pearson
S. Awate,S. K. Bharti,J. A. Sommers,M. Bellani,I Khan,L. Bradley,G. A. King, Y. Seol,V. Vidhyasagar,Y. Wu, T. Abe, K. Kobayashi, K. Shin-ya,H. Kitao,M. S. Wold,D. Branzei,K. C. Neuman,Jr. Brosh R. M.
引用0浏览0引用
0
0
加载更多
作者统计
#Papers: 108
#Citation: 10798
H-Index: 55
G-Index: 103
Sociability: 6
Diversity: 0
Activity: 0
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn