基本信息
views: 42
Career Trajectory
Bio
Research Focus Areas:
Systems Biology
Additional Research:
Bioinformatics. My lab integrates mass spectrometry and experimental cell biology using the yeast model system to understand how networks of coordinated PTMs modulate biological function. Now well into the era of genomics and proteomics, it is widely appreciated that understanding individual genes or proteins, although necessary, is often not sufficient to explain the complex behavior observed in living organisms. Indeed, placing context on the dynamic network of relationships that exist between multiple proteins is now one of the greatest challenges in Biology. Post-translational modifications (PTMs, e.g. phosphorylation, ubiquitination and over 200 others), which can be readily quantified by mass spectrometry (MS), often mediate these dynamic relationships through enhancement or disruption of binding and/or catalytic properties that can result in changes in protein specificity, stability, or cellular localization. We use a combination of tools including quantitative mass spectrometry, yeast genetics, dose-response assays, in vitro biochemistry, and microscopy to explore testable systems-level hypotheses. My current research interests can be grouped into four main categories:(1)coordinated PTM-based regulation of dynamic signaling complexes, (2) cross-pathway coordination by PTMs, (3) PTM networks in stress adaptation, and (4) technology development for rapid PTM network detection.
Research Interests
Papers共 67 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
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期刊级别
合作者
合作机构
ACS Omegano. 36 (2024): 37843-37855
Nature communicationsno. 1 (2024)
C. M. Egbert,L. R. Warr, K. L. Pennington, M. M. Thornton, A. J. Vaughan, S. W. Ashworth,M. J. Heaton,N. English,M. P. Torres,J. L. Andersen
Journal of Molecular Biology/Journal of molecular biologyno. 2 (2023): 167890-167890
Metallomics : integrated biometal scienceno. 3 (2023)
Journal of biological chemistry/The Journal of biological chemistryno. 8 (2023): 104947-104947
Research Square (Research Square) (2021)
Science signalingno. 688 (2021)
bioRxiv (Cold Spring Harbor Laboratory) (2021)
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Author Statistics
#Papers: 68
#Citation: 1571
H-Index: 22
G-Index: 39
Sociability: 5
Diversity: 3
Activity: 2
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