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Research interests
Our tea. ‘Nanobug Oncology Sheffield’ (@Nanobug_Shef) focuses on developing state-of-the-art methods to target anticancer therapies to tumours. For example, we have devised a way to use macrophages as ‘trojans’ to deliver large quantities of cancer-killing virus to both primary and secondary tumours simultaneously (click here). We are currently developing innovative nanomedicine platforms to improve the targeting of drugs to tumours so that healthy tissue remains unharmed. We have used these platforms to protect and deliver oncolytic viruses via the bloodstream so that advanced metastatic cancers can be treated. These include liposomes, nanohydrogels, silk fibroin, extracellular vesicles, and magnetic nanoparticles. For the latter, we recently demonstrated that iron particles purified from magnetotactic bacteria were able to shield viruses and guide them to tumours in models of breast cancer.
研究兴趣
论文共 128 篇作者统计合作学者相似作者
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Virusesno. 8 (2024)
Expert review of clinical immunologyno. 8 (2024): 821-838
Priya Patel, Areej Alghamdi,Gary Shaw,Christopher Legge,Maggie Glover, Danielle Freeman, Harry Hodgetts,Erica Wilson,Faith Howard,Sarah Staniland,Aneurin J Kennerley,Duncan Wood,Robert Moorehead, Charlotte Hadfield,Ola Rominiyi,Jon Griffin,Spencer J Collis, Sam Hyde, Marcus Crossley,Martyn Paley,Munitta Muthana
openalex(2023)
crossref(2023)
Frontiers in virology (2023)
Biomedical EngineeringBiotechnology - Biosensors, Biomaterials and Tissue Engineering - Annual Volume 2023 [Working Title] (2023)
K. Egerton, T.A. Mitchell, P. Gravells, R. Katse, M. Fisher,M. Muthana,C.E. Eyers,P.A. Eyers,H.E. Bryant
ESMO Openno. 1 (2023)
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作者统计
#Papers: 130
#Citation: 2541
H-Index: 22
G-Index: 50
Sociability: 6
Diversity: 0
Activity: 1
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