Since 2006 Manuela has been teaching methods of Health Technology Assessment at Maastricht University and at other organizations. She is the developer and course-coordinator of the 'Cost-effectiveness modelling methods' course of the Health Sciences Research Master. She is a member of the 'Rational Pharmacotherapy' ('Goed Gebruik Geneesmiddelen') committee of the Netherlands Organisation for Health Research and Development (ZonMw) and the ‘Methodology Research Panel’ of the Medical Research Council in the United Kingdom. She leads a health economics evidence review group for the National Institute for Health and Care Excellence NICE) in the United Kingdom. She is the chair of the Scientific Advisory Committee (wetenschapscommissie) of Maastricht UMC+. She is (co-)author of over 180 peer-reviewed papers and is/was supervisor of 20 PhD students.