The Francesconi Lab investigates the chemistry of technetium (Tc) and the lanthanides. As Tc-99m, technetium is the most widely used isotope in the nuclear medicine clinic for diagnosis of disease. The Francesconi Lab, in collaboration with Diatide and Schering, has identified the structures of two recent targeted Tc-99m radiopharmaceuticals, AcuTect™ and NeoTect™ that are now in the clinic for imaging Deep Vein Thrombosis (DVT) and lung tumors, respectively. The lab is transitioning to radiotherapy applications employing rhenium-188 (Re-188), the third row congener of Tc, as well as radiolanthanides.