Lucille L'Heureux

Vertex Pharmaceuticals Canada Incorporated

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论文共 12 篇作者统计合作学者相似作者

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Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles

John J. Court,Carl Poisson,Andrzej Ardzinski,Darius Bilimoria,Laval Chan,Kishan Chandupatla,Nathalie Chauret,Philip N. Collier, Sanjoy Kumar Dasi,Francois Denis, Warren Dorsch,Ganesh Iyer,David Lauffer,Lucille L'Heureux,Pan Li, Brian S. Luisi,Nagraj Mani,Suganthi Nanthakumar,Olivier Nicolas,B. Govinda Rao,Steven Ronkin,Subajini Selliah,Rebecca S. Shawgo,Qing Tang,Nathan D. Waal,Constantin G. Yannopoulos,Jeremy Green

Journal of Medicinal Chemistry（2016）

引用9浏览0WOS引用

Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: non-symmetric inhibitors with potent activity against genotype 1a and 1b

Simon Giroux,Darius Bilimoria,Caroline Cadilhac,Kevin M Cottrell,Francois Denis,Evelyne Dietrich,Nigel Ewing,James A Henderson,Lucille L'Heureux,Nagraj Mani,Mark Morris,Olivier Nicolas,T Jagadeeswar Reddy,Subajini Selliah,Rebecca S Shawgo,Jinwang Xu,Nathalie Chauret,Francoise Berlioz-Seux,Laval C Chan,Sanjoy K Das,Anne-Laure Grillot,Youssef L Bennani,John P Maxwell

Bioorganic & Medicinal Chemistry Letters（2015）

引用4浏览0WOS引用

Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-symmetric inhibitors with diyne and biphenyl linkers

Bioorganic & Medicinal Chemistry Letters（2015）

引用5浏览0WOS引用

Synthesis and Evaluation of NS5A Inhibitors Containing Diverse Heteroaromatic Cores

James A. Henderson,Darius Bilimoria,Monica Bubenik,Caroline Cadilhac,Kevin M. Cottrell,Francois Denis,Evelyne Dietrich,Nigel Ewing,Guy Falardeau,Simon Giroux,Lucille L'Heureux,Bingcan Liu,Nagraj Mani,Mark Morris,Olivier Nicolas,Oswy Z. Pereira,Carl Poisson,T. Jagadeeswar Reddy,Subajini Selliah,Rebecca S. Shawgo,Louis Vaillancourt,Jian Wang,Jinwang Xu,Nathalie Chauret,Francoise Berlioz-Seux,Laval C. Chan,Sanjoy K. Das,Anne-Laure Grillot,Youssef L. Bennani,John P. Maxwell

Bioorganic & medicinal chemistry letters（2015）

引用10浏览0WOS引用

Benzimidazole-containing HCV NS5A inhibitors: effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency

James A Henderson,Darius Bilimoria,Monica Bubenik,Caroline Cadilhac,Kevin M Cottrell,Evelyne Dietrich,Francois Denis,Nigel Ewing,Guy Falardeau,Simon Giroux,Ronald Grey,Lucille L'Heureux,Bingcan Liu,Nagraj Mani,Mark Morris,Olivier Nicolas,Oswy Z Pereira,Carl Poisson,B Govinda Rao,T Jagadeeswar Reddy,Subajini Selliah,Rebecca S Shawgo,Louis Vaillancourt,Jian Wang,Constantin G Yannopoulos,Nathalie Chauret,Francoise Berlioz-Seux,Laval C Chan,Sanjoy K Das,Anne-Laure Grillot,Youssef L Bennani,John P Maxwell

Bioorganic & Medicinal Chemistry Letters（2015）

引用9浏览0WOS引用

Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors

Simon Giroux,Jinwang Xu,T. Jagadeeswar Reddy,Mark Morris,Kevin M. Cottrell,Caroline Cadilhac,James A. Henderson,Olivier Nicolas,Darius Bilimoria,Nagraj Mani,Nigel Ewing,Rebecca Shawgo,Lucille L'Heureux,Subajini Selliah,Anne-Laure Grillot,Youssef L. Bennani,John P. Maxwell

ACS Medicinal Chemistry Letters（2014）

引用15浏览0WOS引用

Hcv Ns5a Replication Complex Inhibitors: Effects Of Substituted Pyrrolidines In Balancing Genotype 1a/1b Potency

James A. Henderson,Bingcan Liu,Simon Giroux,T. Jagadeeswar Reddy,Monica Bubenik,Caroline Cadilhac,Louis Vaillancourt,Guy Falardeau,Carl Poisson,Oswy Pereira,Kevin M. Cottrell,Mark Morris,Olivier Nicolas,Darius Bilimoria,Nagraj Mani,Nigel Ewing,Rebecca Shawgo,Lucille L'Heureux,Subajini Selliah,Anne-Laure Grillot,Youssef L. Bennani,John P. Maxwell

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2014)

引用0浏览0引用

ChemInform Abstract: Docking Ligands into Flexible and Solvated Macromolecules. Part 2. Development and Application of FITTED 1.5 to the Virtual Screening of Potential HCV Polymerase Inhibitors

Christopher R. Corbeil,Pablo Englebienne,Constantin G. Yannopoulos,Laval Chan,Sanjoy K. Das,Darius Bilimoria,Lucille L’Heureux,Nicolas Moitessier

Chem Inform（2008）

引用63浏览0引用

Discovery of Thiophene-2-carboxylic Acids As Potent Inhibitors of HCV NS5B Polymerase and HCV Subgenomic RNA Replication. Part 1: Sulfonamides

Laval Chan,Sanjoy K. Das,T. Jagadeeswar Reddy,Carl Poisson,Mélanie Proulx,Oswy Z. Pereira,Marc Courchesne,Caroline Roy,Wuyi Wang,A. M. Siddiqui,Constantin G. Yannopoulos,Nghe Nguyen‐Ba,Denis Labrecque,Richard C. Bethell,Martine Hamel,Philippe Courtemanche-Asselin,Lucille L’Heureux,Maud David,Olivier Nicolas,Stéphanie Brunette,Darius Bilimoria,Jean Bédard

Bioorganic & medicinal chemistry letters（2004）

引用84浏览0引用

Identification ofN,N-Disubstituted Phenylalanines as a Novel Class of Inhibitors of Hepatitis C NS5B Polymerase

Laval Chan,T. Jagadeeswar Reddy,Mélanie Proulx,Sanjoy K. Das,Oswy Pereira,Wuyi Wang,Arshad Siddiqui,Constantin G. Yannopoulos,Carl Poisson,Nathalie Turcotte,Alexandre Drouin,M. Hicham Alaoui-Ismaili,Richard Bethell,Martine Hamel,Lucille L'Heureux,Darius Bilimoria,Nghe Nguyen-Ba

JOURNAL OF MEDICINAL CHEMISTRY（2003）

引用73浏览0WOS引用

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作者统计

#Papers: 12

#Citation: 293

H-Index: 8

G-Index: 10

Sociability: 4

Diversity: 1

Activity: 0

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