Dr. Li’s research is mainly focused on the development of lipid- and polymer-based nanodelivery systems for targeted delivery of various types of therapeutics including nucleic acids (genes, siRNA, and peptide nucleic acids), proteins, and small molecules (e.g., anticancer agents and antioxidants). Emphases are placed on the development of strategies to overcome cellular and in vivo barriers. Another research project in Dr. Li’s group is farnesoid X receptor (FXR)-mediated gene regulation in vascular cells and hepatic stellate cells. Research in Dr. Li’s lab has been continuously supported by grants from NIH and other funding agencies.