Lisa Topolnik

My research program is focusing on the cellular and synaptic mechanisms involved in coordination and processing of information by the hippocampal GABAergic circuits and how these processes contribute to memory formation and consolidation. A current emphasis is placed on the examining of the inhibitory control of inhibitory interneurons and interneuron dendritic integration. In my laboratory, we use a combination of two-photon laser scanning microscopy, whole-cell patch clamp electrophysiology, optogenetics, single-cell transcriptomics, pharmacogenetics, immunohistochemistry, electron microscopy and genetic approaches in brain slices and in behaving mice.