My research program focuses on SARS-CoV, MERS-CoV and SARS-CoV-2, three highly pathogenic coronaviruses emerged into the human population in the 21st century. While genetically quite distinct, these viruses can cause a similar end stage lung disease including diffuse alveolar damage and acute respiratory distress syndrome. By comparing and contrasting virus systems we aim to identify common and unique regulators of disease; focusing on virus-host interactions and how these interactions can promote virus-induced, immune-mediated disease or conversely, protect the infected host.