Ling-Pei Ho

I am a clinician scientist and lead the Translational Lung Immunology Group at the MRC Human Immunology Unit, University of Oxford. I also co-run the Oxford Interstitial Lung Disease Clinical Service, connecting bench science to the clinics. My research programme sits in the interface between basic/mechanistic research, clinical research and development of new medicines with industrial partners. My group studies how immunological responses impact on mechanisms of lung injury, repair and fibrosis. Projects are divided into mechanistic and translational studies. Current projects include (i) Elucidating the role of resident lung immune cells in alveolar regeneration (ii) Characterizing the phenotype and function of resident interstitial macrophages in lung injury and fibrosis (iii) Defining the contribution of monocyte and macrophages to lung fibrosis and (iv) Defining the immune drivers in fibrotic sarcoidosis In the translational space, we study methods and biomarkers to improve mechanistically-driven stratification and outcome measures in fibrosing lung diseases, primarily idiopathic pulmonary fibrosis and sarcoidosis. I have a significant role in development of early phase clinical trials in immunomodulatory drugs, and chair the UK NIHR Translational Research Collaboration Network.