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We are investigating the cellular and molecular genetic mechanisms underlying vertebrate gastrulation, a crucial period of embryogenesis during which the germ layers are formed and then shaped into the vertebrate body plan with organ rudiments. Gastrulation entails a combination of inductive events that specify cell identities with massive cell movements and rearrangements that fashion the body plan. The complex and dynamic nature of gastrulation makes it a challenging but intellectually fascinating object of study. In humans, 25-50% of pregnancies end in early miscarriages of a largely unknown genetic origin. Moreover, the molecular regulation of tumor growth and metastasis show striking parallels to those underlying gastrulation movements, underscoring the practical significance of gastrulation research.
We are addressing the mechanisms of gastrulation in the zebrafish (Danio rerio), a system that affords a powerful combination of forward and reverse genetic analyses with embryological, cellular and molecular methods. We are also employing embryonic stem cells and tumor cell lines to test whether the new genes and mechanisms we implicate in zebrafish gastrulation are also involved in human development and disease. Our current experiments are focused on the roles of the Wnt, Wnt/Planar Cell Polarity, Stat3 and G-protein coupled receptor signaling pathways and epigenetic factors in the regulation of embryonic polarity and gastrulation movements.
研究兴趣
论文共 174 篇作者统计合作学者相似作者
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Brittney Voigt, Katherine Frazier, Donya Yazdi,Paul Gontarz,Bo Zhang,Diane S Sepich,Lilianna Solnica-Krezel,Ryan S Gray
bioRxiv the preprint server for biology (2024)
The Journal of cell biologyno. 12 (2024)
EMERGING TOPICS IN LIFE SCIENCESno. 4 (2023): 383-396
Jamison Leid,Ryan Gray, Peter Rakita,Andrew L. Koenig, Rohan Tripathy,James A. J. Fitzpatrick,Charles Kaufman,Lilianna Solnica-Krezel,Kory J. Lavine
Biology openno. 7 (2023)
bioRxiv the preprint server for biology (2023)
Benjamin C. Stark,Yuanyuan Gao,Diane S. Sepich, Lakyn Belk, Matthew A. Culver,Bo Hu,Marlene Mekel, Wyndham Ferris,Jimann Shin,Lilianna Solnica-Krezel,Fang Lin,John A. Cooper
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#Papers: 174
#Citation: 9922
H-Index: 51
G-Index: 99
Sociability: 6
Diversity: 0
Activity: 1
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