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职业迁徙
个人简介
I am a senior research fellow at University of Southampton. Currently, I am fortunate to be funded by an Anniversary Fellowship scheme at the University of Southampton, which supports the building of a strong track-record of research, innovation, and impact. My contributions in biomedical science have centred on the study of host-pathogen interactions and developing innovative in vitro model systems to understand underlying mechanisms where I found out that commensals inhibit adhesion, invasion, and metabolism of pathogenic Neisseria. I started tuberculosis (TB) research in my second postdoc employment at Imperial College London, initially focusing on extracellular matrix turnover in various scaffolds. In addition, I studied how matrix metalloproteinases increase pathology and release matrix degradation products in TB. An emerging theme was that the extracellular matrix and 3-dimensional cellular organisation were critical in determining the outcome of infection. Therefore, to provide an experimental platform to understand human TB, I developed the bioelectrospray methodology to dissection the host-pathogen interaction in human TB. This is highly tractable and permits systematic investigation of multiple variables. Insights include an alternative hypothesis about human TB pathology, whereby lung matrix destruction precedes cell death. Moreover, we have also used the model to study the effect of individual cytokines, prostaglandin pathway modulation, immunoaugmentation, modelling antibiotic concentrations, and host-directed therapy. In addition, we have recently identified a novel pathway that can be used to control tuberculosis infection in an early phase. In my latest endeavour, I am looking at the role of matrix stifness on the host-pathogen signalling and early finding reveal exciting findings.
研究兴趣
论文共 46 篇作者统计合作学者相似作者
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Sara C Auld,Amy K Barczak,William Bishai,Anna K Coussens, Intan M W Dewi,Steven C Mitini-Nkhoma, Caleb Muefong, Threnesan Naidoo,Anil Pooran, Cari Stek,Adrie J C Steyn,Liku Tezera,Naomi F Walker
American journal of respiratory and critical care medicine (2024)
Hannah F. Schiff,Naomi F. Walker,Cesar Ugarte-Gil,Marc Tebruegge,Antigoni Manousopoulou,Spiros D. Garbis,Salah Mansour, Pak Ho (Michael) Wong, Gabrielle Rockett, Paolo Piazza,Mahesan Niranjan,Andres F. Vallejo,Christopher H. Woelk,Robert J. Wilkinson,Liku B. Tezera,Diana Garay-Baquero,Paul Elkington
JCI INSIGHTno. 8 (2024)
Mohamed Ahmed,Liku B. Tezera,Nicholas Herbert,Mark Chambers,Michaela T. Reichmann,Kievershen Nargan,Henrik Kloverpris,Farina Karim, Mbali Hlatshwayo, Rajhmun Madensein, Munir Habesh, Monjural Hoque,Adrie J. C. Steyn,Paul T. Elkington,Alasdair J. Leslie
Cellular Microbiology (2024): 1-17
COMMUNICATIONS BIOLOGYno. 1 (2024)
Maria Victoria Humbert,Cosma Mirella Spalluto,Joseph Bell,Cornelia Blume,Franco Conforti,Elizabeth R. Davies,Lareb S. N. Dean,Paul Elkington,Hans Michael Haitchi,Claire Jackson,Mark G. Jones,Matthew Loxham,Jane S. Lucas,Hywel Morgan,Marta Polak,Karl J. Staples,Emily J. Swindle,Liku Tezera,Alastair Watson,Tom M. A. Wilkinson
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作者统计
#Papers: 46
#Citation: 1296
H-Index: 21
G-Index: 31
Sociability: 6
Diversity: 3
Activity: 15
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