In vitro, ex vivo and in silico characterization of biological tissues mechanics. Biomechanical design and preclinical in silico, in vitro and ex vivo evaluation of orthopaedic and spinal devices, including 3D-printed prostheses. Development and revision of ASTM/ISO standards for the mechanical characterization of medical devices. Development of surgical techniques for spine stabilization in patients with osteoporosis, tumors and spinal deformities.